https://www.leukoformula.com/en/tags/bolezn-rozai-dorfmana/Recent content in Rosai-Dorfman Disease on LeukoformulaHugoen-USTue, 02 Jan 2024 11:00:00 +0300https://www.leukoformula.com/en/post/bolezn-rozai-dorfmana-citologiya-limfouzla-15292/Tue, 02 Jan 2024 11:00:00 +0300https://www.leukoformula.com/en/post/bolezn-rozai-dorfmana-citologiya-limfouzla-15292/<p>❗A 55-year-old woman, Rosai-Dorfman Disease. 🔬Cervical lymph node imprint smear.</p> <p>✅Rosai-Dorfman disease is a histiocytosis characterized by nodal or extranodal proliferation of large histiocytes/macrophages with signs of emperipolesis. Intact hematopoietic cells (most often lymphocytes, less often plasma cells, neutrophilic granulocytes, erythrocytes) are present in the cytoplasm of histiocytes. S-100, Oct2, and cyclin D1 expression is detected in histiocytes with emperipolesis. The surrounding area is dominated by small mature lymphocytes and numerous polytypic plasma cells.</p>