Dyserythropoiesis on Leukoformula

MDS Transformation to AML: Bone Marrow Findings

Wed, 10 Jun 2026 10:00:01 +0300

Myelodysplastic syndrome, transformation to acute myeloid leukemia ‼️ Material - bone marrow. Blast count 43%. Myeloid granularity is frequently observed, occasionally Auer rods. Prominent clasmatosis of the cytoplasm is noteworthy. In the erythroid lineage, signs of dyserythropoiesis are noted (intererythroid cytoplasmic bridges, abnormal nuclear shapes). Photos 9,10 - positive reaction for phospholipids in blasts. Also, a positive reaction for myeloperoxidase in 9% of blasts. PAS reaction - in diffuse form. According to IFT results - 45% blasts, myeloid variant of acute leukemia confirmed.

Signs of Dyserythropoiesis in Bone Marrow Aspirate

Mon, 08 Jun 2026 08:00:00 +0300

Bone marrow aspirate. Erythroid cell proliferation. Binucleated erythroblasts with intercellular bridges and megaloblasts are observed.

🙏 The publication was kindly provided by Clinical Diagnostic Laboratory doctor Nana Novikova, CHUZ “KB” RZD-Meditsina" Smolensk.

Bone Marrow Dynamics in Acute Lymphoblastic Leukemia

Mon, 27 Apr 2026 09:00:01 +0300

PATIENT OF THE HEMATOLOGY DEPARTMENT, 63 years old, with ACUTE LYMPHOBLASTIC LEUKEMIA. Upon admission, BLASTOSIS in bone marrow aspirate reached 82.0% (photos 1,2,3), but after prednisone, prescribed by the hematologist, during REPEATED sternal puncture (after 2 weeks), there were no blast cells in the bone marrow aspirate. MACROPHAGES with remnants of phagocytosed material were found (photo 4), and, surrounded by erythroblasts (erythroblastic island, photo 5). ERYTHROID lineage is EXPANDED - 45.1%, with signs of dysplasia (binucleated erythroblasts, and with intercellular bridges, photo 6).

Four-Nucleated Erythrocyte in Bone Marrow Smear

Wed, 15 Apr 2026 08:00:00 +0300

A remarkably beautiful finding: bone marrow aspirate. Presumably, a 4-nucleated erythrocyte. Such morphology is rare and captivating.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZD-Meditsina, Smolensk.

Trinucleated Normoblast in Bone Marrow: A Case Study

Thu, 19 Mar 2026 08:00:00 +0300

Trinucleated normoblast in a bone marrow smear.

🙏 The publication was kindly provided by KDL physician Alla Alekseenkova CHUZ KB RZD-Meditsina, Smolensk

Acute Myeloid Leukemia with Antecedent Myelodysplastic Syndrome

Fri, 06 Mar 2026 10:00:01 +0300

In the bone marrow aspirate of a female patient with acute myeloid leukemia, with antecedent MDS, the number of blast cells is increased to 19.8%, and the erythroid lineage is expanded to 68.0%. Among the cells of the erythroid lineage, megaloblasts and binucleated forms are observed. Mitotic figures are shown in photo 2, and macrophages in photos 3, 5, and 7. In the peripheral blood (photo 9), anisocytosis and poikilocytosis of erythrocytes are present.

Myelodysplastic Syndrome: Bone Marrow Morphology

Mon, 01 Dec 2025 09:46:00 +0300

Patient, 86 years old, admitted for examination to the hematology department. In CBC: leukocytosis, thrombocytopenia, anemia, anisocytosis, poikilocytosis, normoblasts. In bone marrow biopsy: 10% blasts, proliferation of erythroid lineage cells with signs of dyserythropoiesis – megaloblastoid changes, multinuclearity, cytoplasmic vacuolization; mononuclear megakaryocytes are present. MDS can be suspected. Cytogenetic testing is recommended.

Bone Marrow Dyserythropoiesis Morphology in MDS

Wed, 26 Nov 2025 08:15:00 +0300

The patient is under hematological care for MDS. Complete blood count shows two-line cytopenia. Bone marrow aspirate reveals megaloblastoid features, with binucleated erythroblasts (EBC) present – signs of dyserythropoiesis. In photo 1 – what is wrong with the EBC nucleus?

Megaloblasts & Proerythroblast in Bone Marrow Aspirate

Tue, 11 Nov 2025 11:09:00 +0300

Bone marrow aspirate. Proerythroblast, with a round nucleus with delicate reticular chromatin, nucleoli, and binucleated megaloblasts.

🙏 The publication was kindly provided by Clinical Diagnostic Laboratory doctor Nana Novikova, CHUZ “Clinical Hospital” RZD-Medicine, Smolensk.

Dyserythropoiesis in Bone Marrow: Intercellular Bridges

Thu, 16 Oct 2025 10:36:00 +0300

🦴 Bone marrow. Proliferation of erythroid lineage cells with signs of dyserythropoiesis. Do we count bridges between erythroblasts as dysplasia?

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “CB” RZD-Meditsina, Smolensk.

Granulocyte Clasmacytosis in Bone Marrow Aspirate

Tue, 25 Mar 2025 16:00:01 +0300

Correct answer to the problem from the closed club of laboratory hematologists. C. Granulocyte cytoplasmic fragment (clasmacytosis) In the image, in the lower left part of the field, there is an isolated rounded fragment with basophilic cytoplasm, devoid of a nucleus. To its right, a large cytoplasmic fragment with characteristic granulation is clearly visible, which allows interpreting the finding as a fragment of the cytoplasm of a mature granulocyte — a manifestation of clasmacytosis.

Bone Marrow Morphology in Vitamin B12 Deficiency

Tue, 28 Jan 2025 19:30:00 +0300

Microscopy of bone marrow aspirate. Vitamin B12 deficiency disrupts cell cycle coordination, leading to cells appearing in various division phases, slowed maturation, and increased apoptosis. In vitamin B12 deficiency, the normal cell division process in the bone marrow is impaired, especially for actively proliferating cells.

Dyserythropoiesis: Cytoplasmic and Internuclear Bridges

Thu, 16 Jan 2025 08:47:54 +0300

🔬 Signs of dyserythropoiesis. Cytoplasmic and internuclear bridges. A selection of bone marrow aspirate microscopy photos.

❓ How do you interpret the presence of cytoplasmic and internuclear bridges in the presented images? What cell types can you identify in the presented photos?

MDS with Ring Sideroblasts: Bone Marrow Cytology

Tue, 16 Jan 2024 17:38:07 +0300

I suggest considering the diagnosis. Patient is 68 years old. CBC shows pancytopenia: WBC 2.1; PLT 43; Hb 57, RBC 1.91; peripheral blood also shows erythroblasts 10/100 WBC, reticulocytes 1.8%, macrocytes, ovalocytes, neutrophil hypersegmentation. Bone marrow aspirate in photos 1, 2, 3. Its immunophenotyping shows: 74% erythroblasts, 5% myeloblasts, 3% granulocytes, 3% monocytes, 11% lymphocytes. Cytochemistry for sideroblasts in photo 4 (the only cytochemistry we perform, and very rarely, at the request of hematologists).