Hematology
Barr Body in Neutrophil: Morphology of Sex Chromatin
Morphology of the Barr body in a peripheral blood segmented neutrophil: detection of sex chromatin and differential diagnosis during blood smear microscopy.
Tag
Genetics
Oncohematology
Extramedullary Disease in Multiple Myeloma: Forms & Diagnosis
Explore the forms, pathogenesis, and diagnosis of extramedullary disease in multiple myeloma, including clonal migration mechanisms, imaging, and therapeutic approaches.
Hemostasis
Hereditary Macrocytopenic Thrombocytopenia with MYH9 Mutation
Clinical case of MYH9-associated thrombocytopenia: macrothrombocytes, neutrophil inclusions, differential diagnosis with ITP, and genetic confirmation.
Laboratory methods
Phenylketonuria Screening: The Cost of a Lab Error
Clinical case: Delayed phenylketonuria screening led to delayed treatment for a child and a multi-million dollar lawsuit against the laboratory.
Laboratory methods
Dicentromeric Chromosome: Definition and Formation Mechanism
What is a dicentric (dic) in cytogenetics? Structural features of a dicentric chromosome with two centromeres and translocation mechanisms.
Laboratory methods
Karyotyping: Cytogenetic Analysis of Chromosomes
Cytogenetic study and karyotyping: detection of t(9;22) translocation in CML and trisomy 21 on metaphase plates.
Oncohematology
Intravascular Large B-Cell Lymphoma: A Case Study
A clinical case of intravascular large B-cell lymphoma with hemophagocytic syndrome: bone marrow cytology, karyotype, and immunophenotype.
Hematology
Blood Group Determination on the Shroud of Turin
Laboratory findings on blood traces from the Shroud of Turin: hemoglobin detection, determination of blood group AB (IV), and DNA analysis.
Laboratory methods
DNA Molecule Structure: Fundamentals of Molecular Genetics
Features of DNA double helix structure, principles of genetic material organization, and molecular diagnostic methods in the clinical laboratory.
Oncohematology
KMT2A Gene Rearrangements in Acute Myeloid Leukemia
Genetic rearrangements of the KMT2A gene in acute myeloid leukemia: spectrum of partner genes according to the WHO 5th edition classification (WHO 2022).
Laboratory methods
Purified DNA Solution: Causes of High Viscosity
Why purified genomic DNA solutions are highly viscous: physicochemical properties of eukaryotic DNA molecules in the clinical laboratory.
Laboratory methods
Next-Generation Sequencing (NGS): Conference Report
A review of presentations from the NGS scientific and practical conference on high-throughput genomic sequencing, aging biomarkers, and genome editing.