Histiocytosis on Leukoformula

Lymph Node Cytology in Sinus Histiocytosis

Fri, 05 Apr 2024 13:18:00 +0300

🟡HISTIOCYTOSIS ✅In relevant lymph node smears, histiocytes, small lymphocytes, and macrophages with engulfed cytoplasm may be found.

✅Differential diagnosis: Sinus histiocytosis with massive lymphadenopathy. Sinus histiocytosis: mono- and multinucleated macrophages are found in the smear, often surrounded by nuclear debris on a necrotic and inflammatory background.

Langerhans Cell Histiocytosis: Clinical Features and Morphology

Fri, 11 Aug 2023 11:00:00 +0300

🔬Langerhans Cell Histiocytosis. ✅A rare disease, occurring in childhood at a frequency of 3-4 cases per 1 million pediatric population per year, even less frequently in adults. ✅The cause of the disease is unknown. A leading role is attributed to cytokines produced by T-lymphocytes and Langerhans cells in the lesions, which mediate the local accumulation of inflammatory infiltrate (eosinophils, macrophages, giant multinucleated cells). ✅Clinical symptoms include bone involvement – skull vault, tibias, ribs, pelvis, vertebrae, mandible. In 30% of cases, lymph nodes are involved. In 30-40% of cases, skin lesions in the form of dermatoses are observed, less often involvement of the oral mucosa. Bone marrow involvement occurs in children with disseminated forms of the disease. This is accompanied by anemia, thrombocytopenia, and neutropenia. ✅Morphological examination of bone marrow aspirate usually reveals normal cellular composition; single Langerhans cells may be found, but their diagnostic significance is low. Histological examination of bone marrow trephine biopsy is more informative. ✅The diagnosis is confirmed by the detection of proliferation of Langerhans cells expressing CD1a, langerin (CD207), S-100 protein, vimentin, CD68, HLA-DR. ✅Photo source inst:xiaoning.zhang ✅Description source: Lugovskaya S. A., Pochtar M. E. Morphology of bone marrow cells in health and pathology //Tver: Triada. – 2018.

Langerhans Cell Histiocytosis in Bone Marrow

Sat, 13 Nov 2021 11:09:52 +0300

Langerhans Cell Histiocytosis. A rare disease, occurring in childhood at a frequency of 3-4 cases per 1 million pediatric population per year, even rarer in adults. The cause of the disease is unknown. A leading role is attributed to cytokines produced by T-lymphocytes and Langerhans cells in the lesions, which mediate the local accumulation of inflammatory infiltrates (eosinophils, macrophages, giant multinucleated cells). Clinical symptoms include bone lesions – skull vault, tibiae, ribs, pelvis, vertebrae, and mandible. Lymph nodes are involved in 30% of cases. Skin lesions in the form of dermatoses are observed in 30-40% of cases, less commonly lesions of the oral mucosa. Bone marrow involvement occurs in children with disseminated forms of the disease, accompanied by anemia, thrombocytopenia, and neutropenia. Morphological examination of bone marrow aspirate usually reveals normal cellular composition; isolated Langerhans cells may be found, but their diagnostic significance is low. Histological examination of bone marrow trephine biopsy is more informative. The diagnosis is confirmed by the detection of proliferating Langerhans cells expressing CD1a, langerin (CD207), S-100 protein, vimentin, CD68, and HLA-DR. Photo source inst:xiaoning.zhang Description source: Lugovskaya S. A., Pochtar M. E. Morphology of bone marrow cells in norm and pathology //Tver: Triada. – 2018.