Cabot Rings on Leukoformula

Cabot Rings in Erythrocytes: Morphology and Diagnostics

Mon, 23 Jun 2025 14:00:22 +0300

🔬 Cabot ring in an erythrocyte. Bone marrow.

🙏 Photo kindly provided by biologist Alina Kudryashova, Sterlitamak

REFERENCE INFORMATION: Cabot rings are thin, thread-like structures with a reddish-purple color, shaped like a loop or the figure 8, very rarely found inside erythrocytes. These are remnants of mitotic spindle microtubules, indicating a disruption in the normal process of erythroid cell formation. They are detected in megaloblastic (pernicious) anemia, lead intoxication, hematological diseases with impaired erythropoiesis, and other severe anemias. They were first described in 1903 by American physician Richard Clarke Cabot. The finding itself is not a disease but serves as a valuable cytological marker of hematopoietic pathology.

Cabot Rings in Erythrocytes: Morphology and Diagnostics

Tue, 24 Dec 2024 09:00:01 +0300

🔬 Cabot rings are thin, thread-like, ring-shaped or figure-eight inclusions, which are remnants of the nuclear membrane. They are observed in megaloblastic anemias and myelodysplastic syndrome.

🙏 Photos and description were kindly provided by biologist Anna Feditskaya, Luhansk.

Megaloblastic Anemia in a Child: Cabot Rings in Blood Smear

Mon, 04 Nov 2024 15:00:01 +0300

👶 Child is 1.5 years old. 🔬 Cabot rings, macrocytes, basophilic stippling in erythrocytes, and…? 🩸 Blood test parameters: RBC (red blood cells): 3.18 × 10^12/L HGB (hemoglobin): 107.4 g/L (anemia) HCT (hematocrit): 28.1 % MCV (mean corpuscular volume): 88.5 fL MCH (mean corpuscular hemoglobin): 33.8 pg RDW-SD (red cell distribution width, standard deviation): 56.2 fL RDW-CV (red cell distribution width, coefficient of variation): 23 %