Bone Marrow on Leukoformula

Bone Marrow Erythroid Lineage in Multiple Myeloma

Mon, 11 May 2026 08:00:00 +0300

Patient, 71 years old, diagnosed with multiple myeloma.

Complete blood count:

RBC 3.6×10^12/L

HGB 128 g/L

WBC 4.0 g/L

PLT 210×10^9/L

ESR 18 mm/hour.

In the control bone marrow aspirate, after a course of treatment, the erythroid lineage of hematopoiesis is expanded to 47.5% (normal range 14.5-26.5). Binucleated erythrokaryocytes (photo 2, 3) and mitotic figures (photo 5) are observed.

Megakaryocytes in Bone Marrow Aspirate and Thrombopoiesis

Thu, 07 May 2026 08:00:01 +0300

MEGAKARYOCYTES in bone marrow aspirate.

The function of megakaryocytopoiesis is platelet formation.

Up to 5 thousand platelets bud off from each megakaryocyte. The lifespan of platelets is about 10 days.

Emperipolesis in Bone Marrow: Neutrophil in Megakaryocyte

Tue, 05 May 2026 08:00:00 +0300

EMPERIPOLESIS.

The “guest” (neutrophilic granulocyte) embedded in the megakaryocyte can leave the “host” at any time (without changes or consequences for itself).

Thus, ONE CELL PENETRATES ANOTHER, temporarily resides in it, and leaves it without any damage.

Bone Marrow Macrophages: Morphology of Stromal Cells

Mon, 04 May 2026 10:00:02 +0300

BONE MARROW STROMAL CELLS - the diversity of macrophages.

Some macrophages show vacuolization and remnants of phagocytosed material in their cytoplasm.

🙏 The publication was kindly provided by clinical diagnostic laboratory physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.

Emperipolesis and Dysplasia of Megakaryocytes in Bone Marrow

Thu, 30 Apr 2026 09:00:00 +0300

Emperipolesis in megakaryocytic lineage cells, signs of dysplasia. Bone marrow examination, x1000 magnification Romanowsky-Giemsa stain

🙏 The publication was kindly provided by the hematologist of the VETLAB veterinary laboratory network Amira Kuznetsova, Moscow

Myelogram in Suspected Lymphoproliferative Disease

Wed, 29 Apr 2026 08:00:00 +0300

PATIENT is 22 years old. Sternal puncture was prescribed to rule out lymphoproliferative disease.

In peripheral blood - moderate leukocytosis, other parameters are normal.

In the BONE MARROW ASPIRATE, the number of lymphocytes is slightly increased - 22.6% (N 4.3-13.7%), plasma cells 0.6 (N 0.4 - 1.8).

Bone Marrow Erythroid Hyperplasia in Splenomegaly Case

Sat, 25 Apr 2026 08:00:00 +0300

SPLENOMEGALY in a 56-year-old PATIENT. Complete blood count without abnormalities: RBC 4.66×10^{12/L
HGB 142 g/L
WBC 3.43×10}9/L PLT 149 ×10^9/L.

In the bone marrow aspirate, the granulocytic lineage is relatively narrowed (35.4%), lymphocytes are 13.5% (normal 4.3-13.7%), and erythrocaryocyte proliferation is significantly increased (45.0%). Binucleated erythrocaryocytes are observed. Megakaryocytes show preserved functional capacity.

Acute Lymphoblastic Leukemia: Cytochemistry and Blast Morphology

Fri, 10 Apr 2026 10:00:01 +0300

TRILINEAGE cytopenia in a 75-year-old patient. Bone marrow aspirate shows total blast infiltration. The cytoplasm is basophilic with vacuolization. Myeloperoxidase reaction in blasts is negative. PAS reaction is positive in granular form. The morphocytochemical characteristics correspond to lymphoid lineage – a picture of acute lymphoblastic leukemia.

Plasma Cells in Bone Marrow in Multiple Myeloma

Mon, 09 Feb 2026 08:00:01 +0300

The patient was referred for a consultation with a hematologist due to anemia and leukocytosis. Bone marrow was taken, in which the number of plasma cells was increased. At the patient’s next appointment, hospitalization will likely be offered for further examination and treatment of the disease. At this stage, morphologically, multiple myeloma can be suspected.

Megaloblasts and Dyserythropoiesis in Anemia During Pregnancy

Fri, 26 Dec 2025 10:00:01 +0300

🩸 A 35-year-old woman, 24 weeks pregnant. Hemoglobin 75 g/L in blood test. Bone marrow aspirate images show dyserythropoiesis.

✅ Megaloblasts, cytoplasmic bridges, and various mitotic figures are present.

Galactosemia: Bone Marrow Cell Vacuolization

Thu, 11 Dec 2025 11:25:00 +0300

👶 Galactosemia. Infant, 8 months old. Symptoms began after the introduction of milk-based feeding:

🤢 vomiting and poor appetite
📈 enlarged liver
⬇ hypoglycemia
⚡ seizures
🌫 bloating, flatulence
🥛 aversion to fatty foods (slow gastrointestinal motility → nausea)
👁 cataracts — one of the earliest and most characteristic signs

🧫 In the bone marrow: cells with vacuolization and intracellular inclusions — typical for carbohydrate metabolism disorders.

Blood and Bone Marrow Findings in Chronic Lymphocytic Leukemia

Sat, 15 Nov 2025 09:22:00 +0300

In the patient’s CBC, with a confirmed diagnosis of CLL, leukocytosis (92.9) with absolute lymphocytosis (89%) was observed.

In the bone marrow aspirate, there was tumor infiltration – lymphocytes with clumpy, condensed nuclear chromatin. Cytolysis cells were present.

Dendritic Cell Neoplasm: Bone Marrow Cell Morphology

Mon, 23 Jun 2025 20:41:27 +0300

❗ A young woman was admitted with agranulocytosis. Laboratory parameters on admission:

🩸 CBC: Hemoglobin — 85 g/L Red blood cells — 2.7×10¹²/L White blood cells — 0.7×10⁹/L Platelets — 221×10⁹/L

Multiple Myeloma with Normal CBC and Urinalysis Results

Tue, 13 May 2025 19:00:01 +0300

🔍 Unusual case: perfect blood and urine tests, but… myeloma!

A 40-year-old patient presented with shooting lower back pain, but general blood and urine tests showed practically normal results:

MDS with Erythroid Dysplasia of the Bone Marrow

Fri, 19 Jul 2024 12:42:07 +0300

A 65-year-old female patient with pancytopenia in peripheral blood. MDS with hyperplasia and severe dysplasia of the erythroid lineage of the bone marrow.

🔬The case was kindly shared by the Head of the Morphology/IFT Department of the Ha-Emek Medical Center Laboratory, Afula 🇮🇱Israel - Anna Belen.

Myeloperoxidase Staining in Myelomonocytic Leukemia

Thu, 15 Feb 2024 13:00:00 +0300

🔬❗Staining of bone marrow aspirate — with benzidine manufactured in 1974. We decided to check if it would still work… And imagine, it works!

The diagnosis for a 35-year-old man is acute myelomonocytic leukemia (verified by flow cytometry - MPO+).

Intravascular Large B-Cell Lymphoma: A Case Study

Sat, 04 Nov 2023 14:00:00 +0300

😱A clinical case of lymphoma-induced nightmares.

A 56-year-old woman presented to a neurologist with multiple neurological symptoms — nightmares, unusual headaches, and dizziness. She also developed a fever and abdominal pain.

Mitoses in Bone Marrow in B12-Deficiency Anemia

Sun, 24 Sep 2023 16:53:49 +0300

Beautiful mitoses

🦴Bone marrow of a patient with B12-deficiency anemia

Acute Promyelocytic Leukemia: Hypogranular Variant M3v

Wed, 01 Mar 2023 08:00:03 +0300

🔬“Angel Wings” 🩸in the blood of a patient with acute promyelocytic leukemia.

✅The photograph shows a bone marrow aspirate, where atypical promyelocytes have abundant basophilic cytoplasm, as well as a specific nuclear shape (“Angel Wings”🕊 or also called “Butterfly Wings”🦋).

Megakaryocyte Morphology in Bone Marrow Smears

Mon, 04 Jul 2022 14:22:00 +0300

Megakaryocyte (“platelet factory”). Bone marrow smear. What a 🦌 deer!😁