
Artifacts and Inclusions in Lymphocyte Cytoplasm
How to distinguish true cytoplasmic inclusions from fixation and staining artifacts in a blood smear: morphological features and differential diagnosis.
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How to distinguish true cytoplasmic inclusions from fixation and staining artifacts in a blood smear: morphological features and differential diagnosis.

Clinical case: crystalline inclusions in lymphocytes and cytolysis cells in peripheral blood in a 67-year-old woman with a lymphoproliferative disorder.

A clinical example of an immunogram using a flow cytometer: evaluating activated CD3+HLA-DR+ T-lymphocytes and NK cells in inflammatory processes.

A clinical case of hairy cell leukemia in a 65-year-old man: complete blood count parameters, scattergram, and morphology of scalloped and filamentous cells.

A clinical case of hairy cell leukemia: morphology of neoplastic lymphocytes in peripheral blood smear, including scalloped and filiform cell forms.

Morphological features of atypical mononuclear cells (virocytes) in blood smears: nuclear polymorphism, cytoplasmic basophilia, and infection diagnosis.

Morphological features of blasts in blood: high nuclear-cytoplasmic ratio, delicate chromatin, and the role of immunophenotyping in diagnosis.

Clinical case: atypical mononuclear cells (32%) and leukocytosis 21.38×10⁹/L in a 23-year-old female patient. Sysmex WDF and WPC scattergrams, cytology, and leukocyte differential.

Explore the morphological features of Sézary cells: T-lymphocytes with cerebriform nuclei found in peripheral blood in cutaneous T-cell lymphoma and Sézary syndrome.

Features of differential leukocyte count in severe leukopenia: detection of large granular lymphocytes, WDF scattergram analysis, and digital microscopy.