Mantle Cell Lymphoma on Leukoformula

Mantle Cell Lymphoma with Leukemic Phase in Blood Smear

Tue, 07 Apr 2026 14:00:01 +0300

The patient had noted an increase in inguinal, axillary, and cervical lymph nodes, weakness, and fatigue for 7 years, but had not sought medical attention or examination. From late 2025, he experienced a worsening of his condition, a 21 kg weight loss, increased weakness, sweating, subfebrile temperature, and enlargement of all groups of lymph nodes. From February 2026, he developed bone pain and lower back pain. His hemogram showed leukocytes up to 160x10^{9/L, erythrocytes 3.3, hemoglobin 85g/L, platelets 184x10}9/L, ESR 27, and lymphocytosis up to 92%. He was hospitalized due to lymphostasis. The myelogram showed lymphocytes 91%, myelocytes 0.5%, monocytes 1%, band neutrophils 0.5%, and segmented neutrophils 6.75%. In the smear, atypical altered lymphocytes of medium and small size were observed, with round, oval nuclei, lobulated shape, and irregular cytoplasmic contours. Lymphocytes containing one large nucleolus (prolymphocytes?) were frequently seen – as shown in the photos. Immunophenotyping revealed a monoclonal population of B-lymphocytes with the phenotype CD19k+CD5+CD23-CD20+CD79b+CD200-, corresponding to mature B-cell lymphoproliferative disorder, accounting for 82.4% of nucleated cells. The changes are most likely consistent with mantle cell lymphoma.

Mantle Cell Lymphoma Leukemia: Blood Smear Findings

Fri, 13 Mar 2026 08:00:00 +0300

General blood test of a hematology patient: leukocytosis 153.65 × 10⁹/L, erythrocytes 4.72 × 10⁹/L, hemoglobin 118 g/L, platelets - 167 × 10⁹/L. The differential count shows over 90% pathological lymphoid cells with single nucleoli, finely dispersed chromatin, and irregular nuclear shapes. Lymphoma is probable; mantle cell lymphoma cannot be excluded. We are awaiting sternal puncture.

Mantle Cell Lymphoma Cell Morphology in Blood Smear

Tue, 14 Oct 2025 09:11:00 +0300

When counting the leukocyte differential, atypical lymphoid cells were observed. Mantle cell lymphoma was suspected. Sternal puncture and immunophenotyping were performed. The diagnosis was confirmed. 🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.