https://www.leukoformula.com/en/tags/limfopeniya/Recent content in Lymphopenia on LeukoformulaHugoen-USTue, 19 Jul 2022 13:01:00 +0300https://www.leukoformula.com/en/post/deficit-adenozindezaminazy-laboratornaya-7413/Tue, 19 Jul 2022 13:01:00 +0300https://www.leukoformula.com/en/post/deficit-adenozindezaminazy-laboratornaya-7413/<p>ANSWER TO THE CLINICAL CASE FROM JULY 18. TASK DIFFICULTY LEVEL: HIGH. Recurrent respiratory infections. Lymphopenia and hypereosinophilia. 👉🏻Correct answer: 3. LATE-ONSET ADENOSINE DEAMINASE DEFICIENCY. Lymphopenia and hypereosinophilia can reflect both primary and secondary immunodeficiency. ❗In HIV infection, high IgE levels and hypereosinophilia are associated with disease severity. Acquired immunodeficiency syndrome (AIDS) is clinically characterized by hepatosplenomegaly, lymphadenopathy, and, unlike congenital immunodeficiency, the presence of hypergammaglobulinemia. ❗In rare cases, mycobacterial tuberculosis can manifest with peripheral eosinophilia, but the clinical response to penicillin makes this hypothesis unlikely. The child&rsquo;s Mantoux test and QuantiFERON test were normal. ❗Although hypereosinophilia is a hallmark of Churg-Strauss syndrome, typical respiratory manifestations such as treatment-refractory asthma and lymphopenia are absent. ❗❗❗ Recurrent infections, lymphopenia, and hypogammaglobulinemia, as well as the presence of early-onset eczema, are highly indicative of primary immunodeficiency (PID).</p>https://www.leukoformula.com/en/post/klinicheskaya-zadacha-limfopeniya-i-7408/Mon, 18 Jul 2022 12:31:44 +0300https://www.leukoformula.com/en/post/klinicheskaya-zadacha-limfopeniya-i-7408/<p>RECURRENT RESPIRATORY INFECTIONS. LYMPHOPENIA AND HYPEREOSINOPHILIA. 👉🏻A three-year-old girl was referred to the pediatric pulmonology department due to recurrent respiratory infections. Laboratory tests showed: ❗lymphopenia and hypereosinophilia: Hemoglobin: 136 g/L Platelets: 365,000/µL, WBC (total white blood cell count) 4600 cells/µL, Eosinophils: 1950 cells/µL (normal up to 500 cells/µL) Lymphocytes: 200 cells/µL (normal from 1100/µL), All lymphocyte subpopulations were deficient, with almost absent naive T-cells (recent thymic emigrants (RTE): CD45+RA+CD31+ = 19/µL). ❗with a moderate increase in inflammation markers: CRP: 9 mg/L ESR: 31 mm/h ❗Immunoglobulin levels showed hypogammaglobulinemia with elevated IgE: (IgG: 228 mg/dL, IgA: 21 mg/dL, IgM: 10 mg/dL, IgE: 170 IU/mL).</p>