Blood Smear on Leukoformula

Acute Myeloid Leukemia Without Maturation: Blast Morphology

Wed, 13 May 2026 18:00:00 +0300

There is a pronounced recurrence in the arrangement of blast cells in a patient with acute myeloid leukemia without maturation.

🔬 Source: from the archive of Brazilian hematology specialist Marcio Melo

Marginal Zone Lymphoma: Atypical Lymphocytes in Blood Smear

Sat, 02 May 2026 08:00:01 +0300

B-cell MARGINAL ZONE LYMPHOMA (confirmed). In the patient’s CBC - moderate anemia and thrombocytopenia - RBC 3.65×10^{12/L
HGB 116 g/L,
PLT 100×10}9/L, Leukocytosis, RDW 73.22×10^9/L, with absolute lymphocytosis and neutropenia. In the photographs - ATYPICAL lymphocytes. Receiving treatment.

Acute Myeloblastic Leukemia Without Maturation (FAB M1)

Tue, 21 Apr 2026 18:00:00 +0300

A patient with suspected acute leukemia. A complete blood count was performed, and the diagnosis was confirmed.

Marked leukocytosis was noted, with more than 90 percent of cells being myeloblasts. The picture corresponds to acute myeloblastic leukemia without maturation, variant 1 according to the French-American-British classification.

Reticulocytes: Supravital Staining and Clinical Significance

Mon, 20 Apr 2026 11:00:00 +0300

Reticulocytes, peripheral blood, brilliant cresyl blue stain.

Reference information. Reticulocytes are immature cells of the erythroid (red) hematopoietic lineage; they occupy an intermediate position between the oxyphilic erythroblast (normoblast) and the mature erythrocyte.

Babesiosis (Piroplasmosis): Detecting Babesia in Blood Smears

Wed, 15 Apr 2026 09:00:01 +0300

Babesia in dog blood. Microscopic examination of Romanowsky-Giemsa stained dog blood smears revealed intraerythrocytic pear-shaped parasites characteristic of Babesia or Piroplasma, which cause the disease piroplasmosis. In dogs, the pathogen enters the body through the bite of an infected tick.

Blasts in Peripheral Blood Smear with Pancytopenia

Tue, 14 Apr 2026 09:00:01 +0300

Blasts🔬

A patient was admitted to the emergency department. Complete blood count results: HGB -55; PLT- 41; WBC- 2.1. When counting the differential white blood cell count, 19% blasts were found!

Proerythroblast: Morphological Features of the Cell

Tue, 14 Apr 2026 08:00:00 +0300

PROERYTHROBLAST is a young, large cell of the erythroid lineage of hematopoiesis, with a round nucleus containing delicate reticular chromatin, a nucleolus, and intensely basophilic cytoplasm.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina", Smolensk.

Secondary Erythremia: Howell-Jolly Bodies in Blood Smear

Sat, 11 Apr 2026 08:00:00 +0300

🩸 CBC. Male. Secondary erythremia. Howell-Jolly bodies are present in erythrocytes.

🙏 Materials for publication were kindly provided by biologist of the Clinical Diagnostic Laboratory Yulia Guseva, Belorechenskaya Central District Hospital.

Blasts in Peripheral Blood in Acute Leukemia

Wed, 08 Apr 2026 11:00:00 +0300

BLASTS.

Peripheral blood of a patient with acute leukemia.

🙏 The publication was kindly provided by the clinical diagnostic laboratory physician Nana Novikova, CHUZ “Clinical Hospital” RZHD-Meditsina, Smolensk.

Giant Platelet in a Peripheral Blood Smear

Wed, 01 Apr 2026 11:00:00 +0300

Giant platelet in peripheral blood of a cat, x1000 magnification Analysis for manual platelet count, smear prepared from a sodium citrate tube. Patient: mixed breed, 12 years old. Romanowsky-Giemsa staining.

Acute Leukemia in a Rat: Blast Morphology in Blood Smear

Tue, 31 Mar 2026 09:00:00 +0300

Peripheral blood of a rat. Patient: 1 year old.

Total white blood cell count: 258 thousand/µL

Romanowsky-Giemsa stain, magnification x1000

🙏 Publication kindly provided by hematologist of the VETLAB veterinary laboratory network Amira Kuznetsova, Moscow

Myelocyte Morphology in Peripheral Blood Smears

Tue, 31 Mar 2026 08:00:00 +0300

🔍MYELOCYTES

☝🏻Myelocyte nuclei are characterized by alternating lighter and darker areas of chromatin. Nucleoli are often absent in the myelocyte nucleus. Abundant specific cytoplasmic granules are observed in the cytoplasm.

Leukemization of Lymphoma: Atypical Lymphocytes in Blood Smear

Wed, 25 Mar 2026 09:00:01 +0300

A 54-year-old patient from the hematology department, diagnosed with lymphoma.

The complete blood count shows severe anemia, anisocytosis and poikilocytosis of erythrocytes; leukocytosis with lymphocytosis, predominantly represented by abnormal lymphocytes (blasts?), with irregular nuclear shapes, indistinct nucleoli, finely dispersed chromatin, some with vacuolated cytoplasm.

Blood Smear in Beta-Thalassemia Post-Splenectomy

Thu, 19 Mar 2026 09:00:01 +0300

👉🏻Severe anisopoikilocytosis in a patient with beta-thalassemia and splenectomy.

➖This is a hereditary blood disorder in which the synthesis of beta-globin chains is impaired.

🩸Peripheral blood

🔹The smear contains target cells (codocytes) characteristic of thalassemia (photo 1)

Giant Platelets: Morphology and Analyzer Errors

Fri, 13 Mar 2026 10:00:01 +0300

🔍Giant platelet. 😯Its diameter even exceeds that of a red blood cell. 📌An abundance of such platelet forms can lead to incorrect counting by hematology analyzers that use only the impedance method.

Autoimmune Hemolytic Anemia: Blood Smear Morphology

Wed, 25 Feb 2026 18:00:00 +0300

Autoimmune hemolytic anemia caused by warm antibodies

Polychromasia and spherocytes are found in the peripheral blood; circulating erythroblasts and occasional Howell-Jolly bodies may be present.

The disease is caused by immunoglobulin G class antibodies that react with red blood cells at temperatures of 37 degrees Celsius and above. This is the most common form of autoimmune hemolytic anemia.

Acute Leukemia: Blast Morphology in Complete Blood Count

Mon, 23 Feb 2026 09:00:01 +0300

Acute leukemia in a patient who presented with complaints of epistaxis and general weakness. Age 21 years. Blastosis. The last medical examination was in 2025, and CBC parameters were normal.

Bacteremia in Peripheral Blood Smear in Sepsis

Wed, 18 Feb 2026 08:00:00 +0300

Patient from the emergency department. CBC: leukocytes - 2.02 (4.0-9.010^9/L), erythrocytes - 4.44 (3.8-5.710^{12/L), hemoglobin - 142 (117-173 g/L), platelets - 18 (150-400*10}9/L).

Intracellular and extracellular bacteria were found during blood smear microscopy. Procalcitonin - 84.6 (< 0.5 ng/mL).

Acute Leukemia in a Child: Blastemia and Hyperleukocytosis

Wed, 28 Jan 2026 09:00:00 +0300

A child was admitted to the emergency department of a hospital. A 14-year-old girl. Leukocytes - 172. Platelets - 84. Hemoglobin - 111. Blasts - 95%. The child was transferred to the oncohematology department of another institution.

Bacteria and Fungi in Blood Smears: Sepsis or Artifact?

Wed, 10 Dec 2025 12:00:01 +0300

🔍 Guess where the real threat lies?

☠ Normally, there should be NO bacteria and NO fungi in a blood smear. Their appearance is always an alarming signal or an error.

Erythrocyte Inclusions: Cabot Rings & Howell-Jolly Bodies

Fri, 29 Aug 2025 08:00:30 +0300

🩸 Blood smear: details worth noting

🔹 Cabot rings – remnants of the mitotic spindle.

🔹 Howell-Jolly bodies – chromosome remnants in erythrocytes.

🔹 Basophilic stippling – RNA granules in the cytoplasm.

Acute Myeloid Leukemia: Blasts and Auer Rods in Blood

Tue, 24 Jun 2025 08:00:01 +0300

⚠ 97% blasts and Auer rods

Female, 75 years old.

🔬 Complete Blood Count:

Leukocytes — 181.76 ×10⁹/L
Erythrocytes — 2.84 ×10¹²/L
Hemoglobin — 85 g/L
Platelets — 49 ×10⁹/L

🩸 In the peripheral blood smear — 97% blasts, some with Auer rods. Some cells have nuclei with “angel wings” morphology.

Howell-Jolly Bodies in Blood Smear: Morphology & Case Study

Mon, 16 Jun 2025 08:30:00 +0300

🔬 Howell-Jolly bodies in every field of view, +++. Female, 68 years old.

🙏 Photos kindly provided by Clinical Laboratory Diagnostics Physician, Irina Selivanova LLC “Citilab-Ural”, Yekaterinburg

Acute Leukemia in a Child: Blasts in Peripheral Blood

Wed, 11 Jun 2025 10:00:02 +0300

🔬 Newly diagnosed acute leukemia in a 10-year-old girl

Admitted to the emergency department with complaints of fatigue, fever, and painful “sores” on her lips.

📋 Tests:

Leukocytosis 500 × 10⁹/L (!),
Mild anemia,
Thrombocytopenia.

🩸 Upon microscopy:

Blasts in Peripheral Blood Smear: Cell Morphology

Thu, 05 Jun 2025 13:30:00 +0300

🔬 A solitary blast found in a peripheral blood smear.

🙏 Image kindly provided by Clinical Laboratory Diagnostics Physician, Anna Ivanova, Moscow.

Tropical Malaria in Blood Smear: A Clinical Case

Thu, 13 Jun 2024 19:28:00 +0300

🔬 Tropical Malaria. A case from our subscriber.

✅A 40-year-old female patient, a resident of Africa, came to Kaliningrad to her sailor husband. She arrived in autumn in October, and her fever started in winter in December (there were frosts), so the patient thought she had caught a cold. The attending physician ordered a complete blood count. During the leukocyte differential count, we found malaria plasmodia (photos № 1,2). And in the thick film, a “starry sky” (photo №3). In addition to malaria, the patient was also found to have HIV and syphilis. Fatal outcome.

Monocyte Morphology and Differential Diagnosis in Blood Smears

Tue, 24 Oct 2023 12:30:00 +0300

🔬How many monocytes did you find in the picture?

Acute Monocytic Leukemia M5b: Cell Morphology and Immunophenotyping

Mon, 21 Aug 2023 18:45:00 +0300

A case of diagnosing 500,000 leukocytosis!

After processing a blood sample from an outpatient clinic (male, 71 years old) and obtaining this result, doubts arose about its reliability: Leuk. 503×10⁹/L (the analyzer’s cell distribution across all possible channels only added to the uncertainty), Hgb 85 g/L, Platelets 196×10⁹/L. We repeated the analysis, while a smear was prepared and the patient’s history was reviewed. The result was repeated, and in June 2022, the patient was diagnosed with Diffuse Large B-cell Lymphoma of the soft tissues of the back. He underwent chemotherapy. At present (end of July 2023), we have no clinical data.

Borrelia in Peripheral Blood Smear in Lyme Disease

Mon, 14 Aug 2023 17:42:02 +0300

🔬Lyme disease (tick-borne borreliosis). A case from a subscriber doctor from Israel🇮🇱.

✅We diagnose 2-3 cases per year, often as an incidental finding when examining a blood smear for thrombocytopenia (characteristic of this disease).