
Bone Marrow Plasmacytosis: Causes and Differential Diagnosis
Explore the causes of bone marrow plasmacytosis: reactive conditions, MGUS, and multiple myeloma. Understand the features of differential morphological diagnosis.
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Explore the causes of bone marrow plasmacytosis: reactive conditions, MGUS, and multiple myeloma. Understand the features of differential morphological diagnosis.

A clinical case of multiple myeloma: rouleaux formation in peripheral blood smear and trinucleated plasma cells in bone marrow aspirate.

A clinical case of multiple myeloma: bone destruction, rouleaux formation, and up to 18% plasma cells in a bone marrow smear.

A clinical case of multiple myeloma: bone marrow microscopy showing significant plasma cell infiltration and multinucleated atypical plasma cells.

Morphological features of plasma cells: detection of Russell bodies in the cytoplasm and binucleated plasma cells during bone marrow microscopy.

Cytological picture of bone marrow smear: severe infiltration by atypical plasma cells and plasmablasts in multiple myeloma. Cell morphology.

Microscopic bone marrow findings in multiple myeloma: significant plasma cell infiltration, atypical and binucleated plasma cells.

25% plasma cells found in a peripheral blood smear from a 79-year-old male. Morphological features of atypical plasma cells in plasmacytic leukemia.

A clinical case of multiple myeloma: normal CBC and urinalysis, hyperproteinemia, M-gradient on electrophoresis, and bone marrow plasmacytosis.

Bone marrow aspirate morphology: plasma cells with hemophagocytosis and flaming cytoplasm in multiple myeloma cases.

Cytology of a lymph node imprint in a plasmacytoma patient with myeloma: atypical plasma cells and significant neutrophil infiltration.

Cytological features of plasmablastic transformation of multiple myeloma in a lymph node imprint: immunoglobulin crystals, plasmablasts, Ki-67 up to 100%.