Myeloproliferation on Leukoformula

Macrothrombocytes and Giant Platelets in Blood Smear

Mon, 04 May 2026 09:00:00 +0300

Macrothrombocytes and giant platelets in the peripheral blood of a 74-year-old patient with pancytosis of unknown origin. Complete Blood Count (CBC) parameters: WBC - 29.08 (N 3.5-9.5 × 10^{9/L)
RBC - 9.15 (N 3.8-5.8 × 10}12/L) PLT - 765 (N 125-350 × 10^9/L) (norms are indicated for the analyzer on which the measurement was performed) Macrothrombocytes are abnormally large platelets, whose size can be comparable to that of a normal erythrocyte (7-8 µm); if the platelet size exceeds that of an erythrocyte, they are called giant platelets. Macrothrombocytes and giant platelets appear in peripheral blood in response to inflammation (reactive thrombocytosis), activation (activated platelets, often irregularly shaped, with many protrusions - pseudopods), when taking medications (corticosteroids, cytostatics, GM-CSF), in some leukemias with excessive megakaryocytic proliferation (polycythemia vera, essential thrombocythemia, acute megakaryocytic leukemia), in myelodysplastic syndrome (MDS), primary myelofibrosis (PMF) in early stages, as a manifestation of some hereditary diseases - gray platelet syndrome (deficiency of platelet alpha granules), Bernard-Soulier syndrome, MYH9-RD (May-Hegglin anomaly, Fechtner, Epstein, and Sebastian syndromes). Platelets with increased size pass less efficiently through small capillaries, which can lead to the formation of intravascular microthrombi. In some cases, due to genetic mutations (gray platelet syndrome and Bernard-Soulier syndrome), the adhesive capacity of platelets is impaired, and they lose the ability to adhere to the damaged vessel wall, resulting in impaired platelet-vascular hemostasis and increased bleeding throughout life.

Myeloproliferation: Bone Marrow Findings

Wed, 22 Apr 2026 10:00:00 +0300

Sternal puncture of a 48-year-old female patient, peripheral blood data: leukocyte level 15×10 9/L, hemoglobin 143g/L, platelets 483×10 9/L, erythrocytes 5.1×10 12/L, in the bone marrow there is an expanded granulocytic lineage, high thrombocytosis, picture of myeloproliferation..

Chronic Myeloid Leukemia: Blood and Bone Marrow Picture

Tue, 21 Apr 2026 08:00:01 +0300

CML. Chronic myeloid leukemia in a 63-year-old patient. Complete blood count shows leukocytosis with a left shift to myelocytes (photos 6,7). Bone marrow (photos 1, 2,3,4) is rich in cellular elements, polymorphic. Against a background of high cellularity, proliferation of granulocytic cells is enhanced (74.7%), without maturation disturbance (ISN 0.6). Erythroid and lymphoid lineages are narrowed. Erythropoiesis is normoblastic. Megakaryocytic lineage is unchanged, with preserved functional activity.

Platelet Aggregates in Bone Marrow Aspirate

Mon, 02 Feb 2026 08:00:00 +0300

Bone marrow was taken from a patient (91 years old) due to hyperthrombocytosis (1595×10/9), leukocytosis (18.5×10/9), with a left shift in the leukocyte differential count, and moderate anemia. In the photo of the bone marrow aspirate – platelet aggregates.

Blood Smear Morphology in Primary Myelofibrosis

Mon, 27 Mar 2023 09:00:01 +0300

Peripheral blood smear in myelofibrosis

Myelofibrosis, classified as “primary,” belongs to myeloproliferative neoplasms where fibrosis is reactive to a hematological neoplasm. Secondary myelofibrosis represents a bone marrow stromal reaction to a non-hematological disease, for example, it can occur in cases of carcinoma or sarcoma metastasis to the bone marrow. Both of these variants of myelofibrosis will have a rather similar picture upon examination of peripheral blood smears, with some exceptions, which we will consider in more detail.