Microscopy on Leukoformula

Diffuse Large B-Cell Lymphoma in Lymph Node Imprint

Tue, 19 May 2026 10:00:02 +0300

Imprint smear of a cervical lymph node from a 78-year-old woman.

Diagnosis based on HI and IHC results: diffuse large B-cell lymphoma (non-GCB, double expressor).

🙏 The publication was kindly provided by Elena Belyakova, Clinical Laboratory Diagnostics Physician, Pathologist, member of the FLM Hematology Committee, Department of Molecular Morphology, E.E. Eichwald Clinic, I.I. Mechnikov Northwestern State Medical University, St. Petersburg.

Urethral Smear Microscopy: Detecting Neisseria gonorrhoeae

Fri, 15 May 2026 08:00:01 +0300

Today’s patient is a 34-year-old male. Urethral smear. Neisseria gonorrhoeae (gonorrhea) was detected, intracellular Gram-negative diplococci. They typically appear as a “swarm of bees” in a male smear.

Bone Marrow Macrophages: Morphology of Stromal Cells

Mon, 04 May 2026 10:00:02 +0300

BONE MARROW STROMAL CELLS - the diversity of macrophages.

Some macrophages show vacuolization and remnants of phagocytosed material in their cytoplasm.

🙏 The publication was kindly provided by clinical diagnostic laboratory physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.

Bone Marrow Erythroid Hyperplasia in Splenomegaly Case

Sat, 25 Apr 2026 08:00:00 +0300

SPLENOMEGALY in a 56-year-old PATIENT. Complete blood count without abnormalities: RBC 4.66×10^{12/L
HGB 142 g/L
WBC 3.43×10}9/L PLT 149 ×10^9/L.

In the bone marrow aspirate, the granulocytic lineage is relatively narrowed (35.4%), lymphocytes are 13.5% (normal 4.3-13.7%), and erythrocaryocyte proliferation is significantly increased (45.0%). Binucleated erythrocaryocytes are observed. Megakaryocytes show preserved functional capacity.

Babesiosis (Piroplasmosis): Detecting Babesia in Blood Smears

Wed, 15 Apr 2026 09:00:01 +0300

Babesia in dog blood. Microscopic examination of Romanowsky-Giemsa stained dog blood smears revealed intraerythrocytic pear-shaped parasites characteristic of Babesia or Piroplasma, which cause the disease piroplasmosis. In dogs, the pathogen enters the body through the bite of an infected tick.

Proerythroblast: Morphological Features of the Cell

Tue, 14 Apr 2026 08:00:00 +0300

PROERYTHROBLAST is a young, large cell of the erythroid lineage of hematopoiesis, with a round nucleus containing delicate reticular chromatin, a nucleolus, and intensely basophilic cytoplasm.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina", Smolensk.

Acute Leukemia in a Rat: Blast Morphology in Blood Smear

Tue, 31 Mar 2026 09:00:00 +0300

Peripheral blood of a rat. Patient: 1 year old.

Total white blood cell count: 258 thousand/µL

Romanowsky-Giemsa stain, magnification x1000

🙏 Publication kindly provided by hematologist of the VETLAB veterinary laboratory network Amira Kuznetsova, Moscow

Amorphous Urates in Urine Sediment: Laboratory Diagnostics

Sat, 07 Feb 2026 08:00:01 +0300

Acidic urine sediment with pH 5.5

Visually, the urine looks like carrot juice - cloudy with an orange tint; after centrifugation, a bright pink sediment is observed. Microscopy reveals amorphous urates throughout the field of view, with occasional squamous epithelial cells.

Waxy Casts in Urine Sediment Microscopy: Morphology & Diagnosis

Fri, 26 Dec 2025 11:00:25 +0300

Patient from the Department of Nephrology and Hemodialysis. Urine sediment microscopy. Waxy casts. Proteinuria 3.0 g/L.

Waxy casts are dense, homogeneous, wax-candle-like fragments, clearly contoured, straight and convoluted, short and long cylindrical formations. The casts may have cracks and bay-like indentations along their contour. Wide waxy casts form due to the stasis of hyaline and granular casts in dilated distal tubules and collecting ducts of the kidneys. These casts are called terminal casts.

Bacteria and Fungi in Blood Smears: Sepsis or Artifact?

Wed, 10 Dec 2025 12:00:01 +0300

🔍 Guess where the real threat lies?

☠ Normally, there should be NO bacteria and NO fungi in a blood smear. Their appearance is always an alarming signal or an error.

Trichomonads in Gynecological Smear During Pregnancy

Sat, 15 Nov 2025 10:30:00 +0300

A patient from the observation ward, 36 weeks pregnant. Trichomonads were detected during the examination of the vaginal discharge.

🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.

Opisthorchiasis Diagnosis via Duodenal Intubation

Tue, 21 Oct 2025 18:30:02 +0300

🐍 A finding under the microscope!

During duodenal intubation of a patient from the gastroenterology department, we managed to detect Opisthorchis — the causative agent of opisthorchiasis.

Our hospital is one of the few where this diagnostic procedure is still performed.

Neisseria gonorrhoeae in Urethral Smear: Microscopy

Wed, 18 Jun 2025 15:00:00 +0300

🔬 Urethral smear, 30-year-old male.

N.gonorrhoeae +, confirmed by molecular method.

🙏 The publication was kindly provided by clinical laboratory diagnostics physician Alena Azarenkova, St. Petersburg

Blasts in Peripheral Blood Smear: Cell Morphology

Thu, 05 Jun 2025 13:30:00 +0300

🔬 A solitary blast found in a peripheral blood smear.

🙏 Image kindly provided by Clinical Laboratory Diagnostics Physician, Anna Ivanova, Moscow.

Megakaryocyte Morphology in Bone Marrow Smears

Mon, 04 Jul 2022 14:22:00 +0300

Megakaryocyte (“platelet factory”). Bone marrow smear. What a 🦌 deer!😁