Morphology on Leukoformula

Howell-Jolly Bodies & Binucleated Normoblasts in Blood Smear

Tue, 02 Jun 2026 09:00:00 +0300

Newborn infant.

Peripheral blood. Erythrocyte with a Howell-Jolly body (photo 1) and a binucleated normoblast with a Howell-Jolly body (photo 2).

🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.

Diffuse Large B-Cell Lymphoma in Lymph Node Imprint

Tue, 19 May 2026 10:00:02 +0300

Imprint smear of a cervical lymph node from a 78-year-old woman.

Diagnosis based on HI and IHC results: diffuse large B-cell lymphoma (non-GCB, double expressor).

🙏 The publication was kindly provided by Elena Belyakova, Clinical Laboratory Diagnostics Physician, Pathologist, member of the FLM Hematology Committee, Department of Molecular Morphology, E.E. Eichwald Clinic, I.I. Mechnikov Northwestern State Medical University, St. Petersburg.

Acute Myeloid Leukemia Without Maturation: Blast Morphology

Wed, 13 May 2026 18:00:00 +0300

There is a pronounced recurrence in the arrangement of blast cells in a patient with acute myeloid leukemia without maturation.

🔬 Source: from the archive of Brazilian hematology specialist Marcio Melo

Bone Marrow Erythroid Lineage in Multiple Myeloma

Mon, 11 May 2026 08:00:00 +0300

Patient, 71 years old, diagnosed with multiple myeloma.

Complete blood count:

RBC 3.6×10^12/L

HGB 128 g/L

WBC 4.0 g/L

PLT 210×10^9/L

ESR 18 mm/hour.

In the control bone marrow aspirate, after a course of treatment, the erythroid lineage of hematopoiesis is expanded to 47.5% (normal range 14.5-26.5). Binucleated erythrokaryocytes (photo 2, 3) and mitotic figures (photo 5) are observed.

Megakaryocytes in Bone Marrow Aspirate and Thrombopoiesis

Thu, 07 May 2026 08:00:01 +0300

MEGAKARYOCYTES in bone marrow aspirate.

The function of megakaryocytopoiesis is platelet formation.

Up to 5 thousand platelets bud off from each megakaryocyte. The lifespan of platelets is about 10 days.

Emperipolesis in Bone Marrow: Neutrophil in Megakaryocyte

Tue, 05 May 2026 08:00:00 +0300

EMPERIPOLESIS.

The “guest” (neutrophilic granulocyte) embedded in the megakaryocyte can leave the “host” at any time (without changes or consequences for itself).

Thus, ONE CELL PENETRATES ANOTHER, temporarily resides in it, and leaves it without any damage.

Bone Marrow Macrophages: Morphology of Stromal Cells

Mon, 04 May 2026 10:00:02 +0300

BONE MARROW STROMAL CELLS - the diversity of macrophages.

Some macrophages show vacuolization and remnants of phagocytosed material in their cytoplasm.

🙏 The publication was kindly provided by clinical diagnostic laboratory physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.

Emperipolesis and Dysplasia of Megakaryocytes in Bone Marrow

Thu, 30 Apr 2026 09:00:00 +0300

Emperipolesis in megakaryocytic lineage cells, signs of dysplasia. Bone marrow examination, x1000 magnification Romanowsky-Giemsa stain

🙏 The publication was kindly provided by the hematologist of the VETLAB veterinary laboratory network Amira Kuznetsova, Moscow

Bone Marrow Erythroid Hyperplasia in Splenomegaly Case

Sat, 25 Apr 2026 08:00:00 +0300

SPLENOMEGALY in a 56-year-old PATIENT. Complete blood count without abnormalities: RBC 4.66×10^{12/L
HGB 142 g/L
WBC 3.43×10}9/L PLT 149 ×10^9/L.

In the bone marrow aspirate, the granulocytic lineage is relatively narrowed (35.4%), lymphocytes are 13.5% (normal 4.3-13.7%), and erythrocaryocyte proliferation is significantly increased (45.0%). Binucleated erythrocaryocytes are observed. Megakaryocytes show preserved functional capacity.

Acute Myeloblastic Leukemia Without Maturation (FAB M1)

Tue, 21 Apr 2026 18:00:00 +0300

A patient with suspected acute leukemia. A complete blood count was performed, and the diagnosis was confirmed.

Marked leukocytosis was noted, with more than 90 percent of cells being myeloblasts. The picture corresponds to acute myeloblastic leukemia without maturation, variant 1 according to the French-American-British classification.

Reticulocytes: Supravital Staining and Clinical Significance

Mon, 20 Apr 2026 11:00:00 +0300

Reticulocytes, peripheral blood, brilliant cresyl blue stain.

Reference information. Reticulocytes are immature cells of the erythroid (red) hematopoietic lineage; they occupy an intermediate position between the oxyphilic erythroblast (normoblast) and the mature erythrocyte.

Proerythroblast: Morphological Features of the Cell

Tue, 14 Apr 2026 08:00:00 +0300

PROERYTHROBLAST is a young, large cell of the erythroid lineage of hematopoiesis, with a round nucleus containing delicate reticular chromatin, a nucleolus, and intensely basophilic cytoplasm.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina", Smolensk.

Secondary Erythremia: Howell-Jolly Bodies in Blood Smear

Sat, 11 Apr 2026 08:00:00 +0300

🩸 CBC. Male. Secondary erythremia. Howell-Jolly bodies are present in erythrocytes.

🙏 Materials for publication were kindly provided by biologist of the Clinical Diagnostic Laboratory Yulia Guseva, Belorechenskaya Central District Hospital.

Giant Platelet in a Peripheral Blood Smear

Wed, 01 Apr 2026 11:00:00 +0300

Giant platelet in peripheral blood of a cat, x1000 magnification Analysis for manual platelet count, smear prepared from a sodium citrate tube. Patient: mixed breed, 12 years old. Romanowsky-Giemsa staining.

Myelocyte Morphology in Peripheral Blood Smears

Tue, 31 Mar 2026 08:00:00 +0300

🔍MYELOCYTES

☝🏻Myelocyte nuclei are characterized by alternating lighter and darker areas of chromatin. Nucleoli are often absent in the myelocyte nucleus. Abundant specific cytoplasmic granules are observed in the cytoplasm.

Giant Platelets: Morphology and Analyzer Errors

Fri, 13 Mar 2026 10:00:01 +0300

🔍Giant platelet. 😯Its diameter even exceeds that of a red blood cell. 📌An abundance of such platelet forms can lead to incorrect counting by hematology analyzers that use only the impedance method.

Acute Leukemia: Blast Morphology in Complete Blood Count

Mon, 23 Feb 2026 09:00:01 +0300

Acute leukemia in a patient who presented with complaints of epistaxis and general weakness. Age 21 years. Blastosis. The last medical examination was in 2025, and CBC parameters were normal.

Dysgranulocytopoiesis in Blood Smear: Suspected Myelodysplastic Syndrome

Wed, 18 Feb 2026 18:30:00 +0300

A 75-year-old patient reports severe fatigue and weakness for about a month. He has not seen a therapist; his medical history only includes inpatient treatment for surgery (hernia repair).

Plasma Cells in Bone Marrow in Multiple Myeloma

Mon, 09 Feb 2026 08:00:01 +0300

The patient was referred for a consultation with a hematologist due to anemia and leukocytosis. Bone marrow was taken, in which the number of plasma cells was increased. At the patient’s next appointment, hospitalization will likely be offered for further examination and treatment of the disease. At this stage, morphologically, multiple myeloma can be suspected.

Waxy Casts in Urine Sediment Microscopy: Morphology & Diagnosis

Fri, 26 Dec 2025 11:00:25 +0300

Patient from the Department of Nephrology and Hemodialysis. Urine sediment microscopy. Waxy casts. Proteinuria 3.0 g/L.

Waxy casts are dense, homogeneous, wax-candle-like fragments, clearly contoured, straight and convoluted, short and long cylindrical formations. The casts may have cracks and bay-like indentations along their contour. Wide waxy casts form due to the stasis of hyaline and granular casts in dilated distal tubules and collecting ducts of the kidneys. These casts are called terminal casts.

Galactosemia: Bone Marrow Cell Vacuolization

Thu, 11 Dec 2025 11:25:00 +0300

👶 Galactosemia. Infant, 8 months old. Symptoms began after the introduction of milk-based feeding:

🤢 vomiting and poor appetite
📈 enlarged liver
⬇ hypoglycemia
⚡ seizures
🌫 bloating, flatulence
🥛 aversion to fatty foods (slow gastrointestinal motility → nausea)
👁 cataracts — one of the earliest and most characteristic signs

🧫 In the bone marrow: cells with vacuolization and intracellular inclusions — typical for carbohydrate metabolism disorders.

Erythrocyte Inclusions: Cabot Rings & Howell-Jolly Bodies

Fri, 29 Aug 2025 08:00:30 +0300

🩸 Blood smear: details worth noting

🔹 Cabot rings – remnants of the mitotic spindle.

🔹 Howell-Jolly bodies – chromosome remnants in erythrocytes.

🔹 Basophilic stippling – RNA granules in the cytoplasm.

Dendritic Cell Neoplasm: Bone Marrow Cell Morphology

Mon, 23 Jun 2025 20:41:27 +0300

❗ A young woman was admitted with agranulocytosis. Laboratory parameters on admission:

🩸 CBC: Hemoglobin — 85 g/L Red blood cells — 2.7×10¹²/L White blood cells — 0.7×10⁹/L Platelets — 221×10⁹/L

Howell-Jolly Bodies in Blood Smear: Morphology & Case Study

Mon, 16 Jun 2025 08:30:00 +0300

🔬 Howell-Jolly bodies in every field of view, +++. Female, 68 years old.

🙏 Photos kindly provided by Clinical Laboratory Diagnostics Physician, Irina Selivanova LLC “Citilab-Ural”, Yekaterinburg

Blasts in Peripheral Blood Smear: Cell Morphology

Thu, 05 Jun 2025 13:30:00 +0300

🔬 A solitary blast found in a peripheral blood smear.

🙏 Image kindly provided by Clinical Laboratory Diagnostics Physician, Anna Ivanova, Moscow.

MDS with Erythroid Dysplasia of the Bone Marrow

Fri, 19 Jul 2024 12:42:07 +0300

A 65-year-old female patient with pancytopenia in peripheral blood. MDS with hyperplasia and severe dysplasia of the erythroid lineage of the bone marrow.

🔬The case was kindly shared by the Head of the Morphology/IFT Department of the Ha-Emek Medical Center Laboratory, Afula 🇮🇱Israel - Anna Belen.

Monocyte Morphology and Differential Diagnosis in Blood Smears

Tue, 24 Oct 2023 12:30:00 +0300

🔬How many monocytes did you find in the picture?

Mitoses in Bone Marrow in B12-Deficiency Anemia

Sun, 24 Sep 2023 16:53:49 +0300

Beautiful mitoses

🦴Bone marrow of a patient with B12-deficiency anemia

Acute Promyelocytic Leukemia: Hypogranular Variant M3v

Wed, 01 Mar 2023 08:00:03 +0300

🔬“Angel Wings” 🩸in the blood of a patient with acute promyelocytic leukemia.

✅The photograph shows a bone marrow aspirate, where atypical promyelocytes have abundant basophilic cytoplasm, as well as a specific nuclear shape (“Angel Wings”🕊 or also called “Butterfly Wings”🦋).

Megakaryocyte Morphology in Bone Marrow Smears

Mon, 04 Jul 2022 14:22:00 +0300

Megakaryocyte (“platelet factory”). Bone marrow smear. What a 🦌 deer!😁