https://www.leukoformula.com/en/tags/neyrosifilis/Recent content in Neurosyphilis on LeukoformulaHugoen-USWed, 25 Dec 2024 17:00:20 +0300https://www.leukoformula.com/en/post/diagnostika-neyrosifilisa-reakciya-rif-v-likvore-5756/Wed, 25 Dec 2024 17:00:20 +0300https://www.leukoformula.com/en/post/diagnostika-neyrosifilisa-reakciya-rif-v-likvore-5756/<p>Detection of <em>T. pallidum</em> antibodies in cerebrospinal fluid (CSF) using the immunofluorescence assay (IFA).</p> <p>Treponemal tests (such as IFA) have high sensitivity (90-100%) but are not sufficiently specific and can be positive in forms of syphilis not accompanied by nervous system involvement. The presence of treponeme-specific antibodies in CSF is recognized as a necessary but insufficient condition for confirming a diagnosis of &ldquo;neurosyphilis,&rdquo; as these antibodies may be a consequence of passive diffusion from the systemic bloodstream due to their high concentration there.</p>