Plasmacytes on Leukoformula

Myeloma Transformation to Plasmablastic Leukemia

Mon, 29 Jun 2026 10:00:01 +0300

In a 64-year-old patient with a diagnosis of multiple myeloma, transformation into plasmablastic leukemia occurred. Photos 1-3 (bone marrow aspirate); photos 5,6 (peripheral blood).

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “CB” RZD-Meditsina, Smolensk.

Bone Marrow Plasma Cell Morphology in Myeloma

Mon, 15 Jun 2026 09:00:00 +0300

Plasma cells in the bone marrow aspirate of an 86-year-old female patient. Diagnosed with multiple myeloma.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZD-Meditsina" Smolensk.

Bone Marrow Plasmacytosis in Multiple Myeloma

Fri, 12 Jun 2026 09:00:01 +0300

Multiple myeloma 🔴 Material - bone marrow. Patient 65 years old. Number of plasma cells in the bone marrow is 88%, binucleated cells are present.

🙏 The publication was kindly provided by Ekaterina Nozdrina, Omsk.

Bone Marrow Plasmocyte Morphology in Myeloma

Tue, 05 May 2026 09:00:00 +0300

Sternal puncture of a 63-year-old patient with suspected multiple myeloma. Peripheral blood showed anemia, elevated ESR. Bone marrow was cellular, with 15% plasmocytes. Cytoplasmic clasmatosis, mitotic figures of the plasma cell lineage, and binucleated plasmocytes were observed. Megakaryocytes were active with good platelet budding.

Bone Marrow Plasmocyte Morphology in Multiple Myeloma

Sat, 14 Mar 2026 08:00:01 +0300

Sternal puncture of a 70-year-old patient diagnosed with multiple myeloma, with 74% plasmocytes. Many cells show more delicate, immature chromatin; clasmacytosis of the cytoplasm is also observed, along with the presence of immunoglobulin granules, occasional mitotic figures of the plasma cell lineage, and flaming plasmocytes. Rouleaux formation of erythrocytes is noted. Peripheral blood data: leukocytes - 4.93 × 10^{9 /L, erythrocytes - 3.26 × 10}9 /L, hemoglobin - 87 g/L, platelets - 367 × 10^9 /L. Progression of the disease cannot be excluded.

Bone Marrow Morphology in Multiple Myeloma

Thu, 12 Mar 2026 08:00:00 +0300

A 62-year-old patient with peripheral blood data: leukocytes 6.25 ×10 9/L, erythrocytes 4.87×10 9/L, hemoglobin 142 g/L, platelets 309 ×10 9/L, is being monitored with a diagnosis of multiple myeloma. Sternal puncture was performed for control. The bone marrow is cellular, with 2.5% plasma cells. Clasmatosis of the cytoplasm is observed, and erythropoiesis is normoblastic.

Plasma Cells in Blood Smear: Morphology and Flame Cells

Sat, 28 Feb 2026 08:00:00 +0300

PLASMA CELLS. Flame cell - in photo 3.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZD-Meditsina" Smolensk.

Bone Marrow in Multiple Myeloma Remission: A Case Study

Fri, 20 Feb 2026 09:00:00 +0300

🔬 Multiple Myeloma. Remission under the microscope.

In a 74-year-old patient with multiple myeloma in remission, the bone marrow picture appears calm and convincing.

In the bone marrow aspirate, the lymphoid lineage is not expanded. The total content of lymphocytes and plasma cells is 10.5%:

Macrophages and Emperipolesis in Bone Marrow Aspirate

Wed, 28 Jan 2026 08:00:00 +0300

Bone marrow was taken for diagnostic purposes. Many interesting findings were observed in the bone marrow aspirate of the examined patient. A large number of macrophages with remnants of phagocytosed material. How many are in photo 1? If I’m not mistaken - 8. In photos 2,3,4,5 - one macrophage each. In photo 6 - beautiful plasma cells with cytoplasmic inclusions and mitosis. In photo 7 - an unusual, binucleated plasma? cell. In photo 8 - a hypersegmented neutrophil with sex chromatin. In photo 9 - a megakaryocyte with the phenomenon of emperipolesis.

Bone Marrow Plasmacytosis: Causes and Differential Diagnosis

Sat, 27 Dec 2025 08:41:00 +0300

An increased number of plasma cells in the bone marrow is not always a malignant process.

Besides multiple myeloma, there are a number of conditions in which an increase in the number of plasma cells can be detected in the bone marrow. In many cases, this is an immune system reaction, rather than a manifestation of a neoplastic disease.

Multiple Myeloma: Plasma Cells in Myelogram

Thu, 20 Nov 2025 09:10:00 +0300

Clinical case from a subscriber.

A patient from the pulmonology department. Admitted with complaints of fever up to 39 degrees Celsius, shortness of breath, and chest pain during deep breathing. Ill for 3 weeks. At home, took Sumamed without effect. From the medical history: smoked for 50 years, quit 1 month ago. In the summer, experienced weakness and pain in the lumbar spine. Hemoglobin 105 g/L. Pain appeared in the thoracic spine and ribs. Admitted by ambulance with suspected pneumonia. MSCT of the chest organs showed a picture of left-sided bronchopneumonia S4. Multifocal lesions of the thoracic vertebrae and ribs with signs of destruction. Consulted by a hematologist. The myelogram showed an increase in the number of plasma cells up to 18%, with binucleated cells present. Erythrocytes showed aggregation in the form of “rouleaux”.

Multiple Myeloma: Plasma Cells in Bone Marrow

Wed, 12 Nov 2025 10:09:00 +0300

A patient with myeloma (multiple myeloma). In the bone marrow - plasma cell infiltration. Multinucleated plasma cells are observed.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZD-Meditsina" Smolensk.

Russell Bodies and Binucleated Plasma Cells in Bone Marrow

Tue, 04 Nov 2025 09:15:00 +0300

Plasma cells with Russell bodies in the cytoplasm, and binucleated plasma cells.

🙏 The publication was kindly provided by KDL physician Nana Novikova, CHUZ “KB” RZHD-Meditsina, Smolensk.

Plasmacytic Leukemia: Plasma Cells in Peripheral Blood Smear

Tue, 16 Sep 2025 11:15:00 +0300

Peripheral blood smear from a 79-year-old male. 25% plasma cells were found. 🙏 This publication was kindly provided by clinical laboratory diagnostics physician Alena Azarenkova

Plasmablastic Transformation of Myeloma in Lymph Node Imprint

Wed, 26 Feb 2025 20:54:38 +0300

🔬 Lymph node imprint from a patient with a previously diagnosed multiple myeloma. Progression occurred during chemotherapy. The photographs show fields of plasmacytes and plasmablasts, with crystalline immunoglobulin inclusions in the cell cytoplasm, as well as free-lying crystals. The proliferative activity index Ki-67 of these tumor cells is close to 100% according to IHC data. This is how plasmacytoma (plasmablastic transformation of multiple myeloma) appears.

Multinucleated Plasma Cells in Multiple Myeloma

Tue, 11 Feb 2025 10:30:00 +0300

🔬 Multinucleated and uninucleated plasma cells.

Female, 68 years old. Diagnosis: multiple myeloma since 2022. Both uninucleated and multinucleated plasma cells are found in the bone marrow aspirate. A total of 13.4% plasma cells were detected. 🙏 The clinical case was kindly provided by KDL doctor Katerina Yangildina, KDL OOKB named after V. I. Voynov, Orenburg.

Multiple Myeloma: Bone Marrow Cell Morphology

Sat, 01 Feb 2025 14:00:01 +0300

Clinical case. Multiple myeloma in a 73-year-old patient.

🔬 In the myelogram: proplasmacytes - 9%, plasma cells - 38%. Bone marrow is hypercellular, with erythroid lineage narrowing. Multinucleated plasma cells are observed.

Morphology of Vacuolated Plasma Cells in Blood Smears

Mon, 27 Jan 2025 11:47:08 +0300

🔬 Plasma Cells

Plasma cells have a compact, usually eccentrically located nucleus with coarse chromatin. Nucleoli are not detectable. The cytoplasm is intensely basophilic, bright, and larger in volume than the nucleus. The cells shown in the photographs contain a large number of vacuoles, appearing lacy and even delicate. All cells are from the same slide.

Multinucleated Plasma Cells in Bone Marrow

Fri, 06 Dec 2024 11:04:11 +0300

Multinucleated plasma cells. Sternal bone marrow aspirate.

🙏 Smear photos were kindly provided by Kristina Yurievna, Clinical Laboratory Diagnostics Physician, BU “RCB”, Cheboksary

Rouleaux Formation and Plasma Cells in Peripheral Blood Smear

Wed, 06 Nov 2024 12:30:00 +0300

📝 Patient: Male, 42 years old. ESR: 123 mm/h! 📊 Complete Blood Count results: Hemoglobin: 94 g/L Red blood cells: 3.05 million/µL White blood cells: 8.46 thousand/µL Platelets: 38 thousand/µL Red blood cell aggregation observed as “rouleaux formation” ❓ Question to colleagues: What are your diagnostic hypotheses?

Plasma Cells in Blood Smear in Multiple Myeloma

Thu, 18 Jul 2024 09:00:01 +0300

Very rarely in myeloma do plasma cells enter the peripheral blood. But in this case, the diagnosis began with the detection of plasma cells in the smear. There were 6% of them. We differentiate them from lymphocytes and erythroblasts. WBC 11.6; Hb 113; PLT 212. Further, light chains were detected (see photo) Bone marrow aspiration had not yet been performed.

Plasma Cell Morphology and Atypical Forms

Mon, 17 Jun 2024 11:52:41 +0300

Morphological diversity of plasma cells:

“Flaming” plasma cells - pink staining of the cytoplasm at the periphery;
Grape-like cells (Mott cells) with Russell body inclusions (hyaline-like droplets in the cytoplasm, formed during immunoglobulin overproduction by a plasma cell);
Cells with rod-like inclusions in the cytoplasm, similar to Auer rods.

✅ Photos and description kindly provided by the clinical laboratory diagnostics physician of S. P. Botkin City Clinical Hospital - Anna Syrovtseva.

Agranulocytosis: Myelogram in Granulopoiesis Reduction

Tue, 23 Jan 2024 10:21:00 +0300

🔬Clinical case from a doctor from 🇮🇱Israel - Anna Belen. Suggest a diagnosis. The picture somewhat resembles the previous case of leukopenia, absence of granulocytic lineage. 16-year-old female patient, nasopharyngitis. Peripheral blood shows leukopenia, anemia: WBC 0.94; neutrophils 0.02, 2%; hemoglobin 111; platelets 204. Bone marrow aspirate in the photos. Immunophenotyping: blasts not detected, granulocytes absent. Histology: moderate bone marrow hypoplasia with severe myeloid hypoplasia and myeloid lineage maturation arrest. Increased number of plasma cells. Blasts not detected. Slight erythroid lineage proliferation. Megakaryocytes present, without significant proliferation.

Oropharyngeal Plasmacytoma: Cytological Diagnosis

Wed, 29 Nov 2023 12:59:25 +0300

❗A task from a member of the closed club of hematologists. 👉The photographs show microscopy of a cytological preparation from a lesion with areas of inflammation and necrosis in the oropharynx of a 60-year-old patient.