Prolymphocytes on Leukoformula

T-Cell Prolymphocytic Leukemia: Morphology and Phenotype

Mon, 26 Aug 2024 19:15:16 +0300

✅ A task from the closed club of laboratory hematologists. ❗Patient 81 years old. CBC: WBC 444×10^9/L !!!, Hb 110, PLT 62. Peripheral blood morphology in the photos. 💡 The phenotype is quite characteristic: Positive: CD45, mCD3, CD4, CD5bright, CD7bright, CD2, CD27, CD28, TCR-AB, CD45RO. Negative: CD34, CD117, TDT, CD1a, CD8, CD10, CD56, CD57, TCR-GD, CD45RA.

Distinguishing Prolymphocytes from Blasts in CLL

Tue, 14 Nov 2023 13:22:09 +0300

⚠️Urgent help is needed for our subscriber! ✅Blasts or prolymphocytes in a blood smear? Hello colleagues! Please help with this patient! A 80-year-old woman. Hemoglobin 99 g/L, Platelets 79 thousand/µL, Leukocytes 171.8 thousand/µL. →According to her daughter, she has a history of CLL (chronic lymphocytic leukemia). Opinions with colleagues are completely divided (Thank you in advance🙏

Chronic Lymphocytic Leukemia with Prolymphocyte Morphology

Fri, 14 Jul 2023 15:00:00 +0300

Chronic lymphocytic leukemia with prolymphocyte morphology. 🔬In the photo: peripheral blood smear. 🩸In the complete blood count: leukocytosis: 562 thousand/µL! ✅IPT→ In the analyzed sample, the lymphocyte content is 96.8%, of which B-cells (CD19+) are 98.0%, T-cells (CD3+) are 1.1%. ✅Conclusion: monoclonal proliferation of B-lymphocytes with immunophenotype: ✅CD19 lambda+ /CD5+ /CD23+ /CD200+ /CD43+ /CD20dim+ /CD22dim+ /CD38+ /CD10-, which corresponds to chronic lymphocytic leukemia. No immunophenotypic data supporting acute leukemia were obtained. 👉We thank Olga Raeva, clinical laboratory diagnostics physician at Pavlov First Saint Petersburg State Medical University, for providing this clinical case.