Symptoms on Leukoformula

Leukemia Cutis: Specific Skin Lesions in Leukemia

Thu, 28 Nov 2019 15:32:53 +0300

Infiltration of the skin by leukemic blast cells, or leukemia cutis, most commonly occurs in monocytic forms of acute myeloid leukemia (AML). Leukemia cutis can also develop in any acute or chronic form of leukemia. As shown in these photographs of AML cases with leukemia cutis, this condition is highly variable and can include widespread papules, nodules, macules, palpable purpura, plaques, or ulcers. Pain and itching are rare. Prepared by: Dermatologist Yulia Sukhoruchko, participant of the Closed Club of Hematologists

Major Beta-Thalassemia: External Signs and Symptoms

Tue, 12 Nov 2019 15:13:00 +0300

Beta-thalassemia is a congenital hemolytic anemia characterized by reduced synthesis of beta-polypeptide chains of hemoglobin. Major beta-thalassemia manifests at 1 to 2 years of age with symptoms of severe anemia and bone marrow hyperactivity. Upon examination, icterus of the skin is visible. Due to increased destruction of red blood cells, hemosiderin is formed and accumulates in tissues. Hemosiderosis manifests as spots of various sizes and shapes, ranging in color from yellow to brown or black. Excessive bone marrow proliferation causes thickening of the skull bones and malar prominences. The face acquires mongoloid features.

Cold Agglutinin Disease: Symptoms and Diagnosis

Sat, 09 Nov 2019 15:57:06 +0300

Cold agglutinin disease is an autoimmune hemolytic anemia caused by IgM class antibodies, which are cold agglutinins, maximally active at temperatures from 0 to 37 °C. Patients complain of pain in their fingers, which occurs outdoors in winter. After prolonged exposure to cold, there is a risk of developing gangrene of the fingers. Blood tests show autoagglutination of erythrocytes, which disappears when heated to 37 °C.

Koilonychia and Atrophic Glossitis in Iron Deficiency

Mon, 28 Oct 2019 10:29:04 +0300

Smooth tongue and koilonychia in iron deficiency. In iron deficiency anemia, atrophy of the tongue papillae, predominantly located in its anterior part, is observed. The tongue becomes bright red and smooth, as if polished, with deep folds appearing on it. Along with this, the tip of the tongue becomes extremely sensitive to all mechanical and chemical irritations. Sometimes cracks appear at the corners of the mouth – angular stomatitis. Koilonychia, a condition also called “spoon-shaped nails,” is also caused by chronic iron deficiency. In this type of dystrophy, the nails become thin and brittle, a depression forms in the middle, and the edges, conversely, curve upwards.

Rendu-Osler Disease: Telangiectasias and Anemia

Mon, 21 Oct 2019 15:25:03 +0300

Rendu-Osler disease is a hereditary condition based on vascular endothelial insufficiency, resulting in the formation of multiple angiomas and telangiectasias on various areas of the skin and mucous membranes of the lips, mouth, and internal organs, which bleed. Patients often suffer from iron deficiency anemia due to recurrent gastrointestinal bleeding from gastrointestinal telangiectasias. Vascular malformations on the face, lips, and hands are visible upon examination. Post prepared by: Yulia Sukhoruchko, dermatologist-venereologist, member of the closed club of hematologists.