Thrombosis on Leukoformula

Hyperleukocytosis and Leukostasis Syndrome in Acute Leukemias

Mon, 20 Nov 2023 09:00:03 +0300

🩸This week is dedicated to emergency, extreme hematology!

👉In photo 1: extreme hyperleukocytosis in peripheral blood of a patient with acute T-lymphoblastic leukemia (T-ALL). Photo 2: Peripheral blood sample with an excessive number of leukemic blasts (T-ALL) – left, compared to normal blood – right. Photo 3: Leukapheresis (procedure for removing leukocytes from the blood).

Venous Thrombosis During Chemotherapy for Burkitt Lymphoma

Wed, 27 Sep 2023 10:00:01 +0300

❗Clinical case. Venous thrombosis during chemotherapy in a child with Burkitt lymphoma. Download: PDF file below the patient’s pedigree.

Fibrin Formation and Fibrinolysis in Hemostasis

Wed, 24 Aug 2022 17:06:00 +0300

The third phase of blood coagulation is fibrin formation (diagram in the photo). After fibrin stabilization, which, together with blood cells, forms the primary red thrombus, two main processes of the post-coagulation phase begin: spontaneous fibrinolysis and retraction, ultimately leading to the formation of a hemostatically complete definitive thrombus. Normally, these two processes occur in parallel. Physiological spontaneous fibrinolysis and retraction contribute to the compaction of the thrombus and its hemostatic functions. The plasmin (fibrinolytic) system and fibrinase (factor XIIIa) actively participate in this process. Spontaneous (natural) fibrinolysis reflects a complex reaction between the components of the body’s plasmin system and fibrin. The plasmin system consists of four main components: plasminogen, plasmin (fibrinolysin), activators of fibrinolysis proenzymes, and its inhibitors. Disruptions in the balance of plasmin system components lead to pathological activation of fibrinolysis.

Hematology Case: Retinal Vein Occlusion and Paraprotein

Sun, 27 Dec 2020 15:26:09 +0300

Hematology Case A 69-year-old man presented to an ophthalmologist with sudden vision loss. The ophthalmologist found retinal vein thrombosis (branch occlusion). He also noticed enlarged lymph nodes on the right side of his neck. He had no other abnormal physical signs. He was generally healthy. Complete blood count: Hb 98 g/L WBC 7.6 x 10 (9)/L Other tests show: Total protein 94 g/L. Protein electrophoresis shows a paraprotein identified as IgM kappa (36 g/L) Bone marrow aspirate microscopy is shown in the photo below. What is the most likely diagnosis? Vote. The answer will be in the group news tomorrow.