Inflammation on Leukoformula

Toxic Granulation of Neutrophils: Causes and Morphology

Fri, 20 Dec 2024 19:00:00 +0300

🔬 Toxic granulation of neutrophils is the appearance of large basophilic granules in the cytoplasm of neutrophils. It results from impaired granule maturation in the bone marrow, which is associated with protein denaturation under the influence of an infectious or toxic agent. The appearance of neutrophils with toxic granulation indicates the severity of the inflammatory process. This phenomenon is observed in sepsis, peritonitis, massive purulent-destructive processes, severe infections (e.g., pneumonia or endocarditis), burns, extensive trauma, and in some cases after chemotherapy.

Knyazkov-Dele Bodies in Neutrophils: Morphology and Significance

Mon, 16 Sep 2024 09:38:28 +0300

Knyazkov-Dele bodies. Light blue, bluish inclusions in the cytoplasm of neutrophils. They consist of ribosomal RNA and remnants of the rough endoplasmic reticulum. They appear in reactive conditions (inflammatory, infectious processes).

Granulomatous Inflammation in Lymph Node Imprint Cytology

Sat, 13 Jul 2024 14:30:00 +0300

Woman, 81 years old. Cervical lymph node (2.9x2.4x0.7 cm). The lymph node imprint shows numerous granulomas, consisting of epithelioid histiocytes and sparse lymphocytes. Giant multinucleated cells are present. Histological examination results indicate granulomatous inflammation of sarcoid type.

Ferritin Test Limitations in Inflammation and Fever

Fri, 25 Nov 2022 16:22:37 +0300

LIMITATIONS OF THE FERRITIN TEST FOR DIAGNOSING IDA. During a fever, a doctor recommends a ferritin test during an online consultation because the MCHC level is low. 📢REMEMBER! In the presence of inflammation, ferritin will not show true iron deficiency. Although serum ferritin is an excellent test for diagnosing iron deficiency anemia (including latent iron deficiency), it is not recommended to perform it during an inflammatory reaction. Ferritin is an acute phase protein of inflammation. And if MCHC decreases during a fever, it is quite likely due to the blockage of iron stores utilization by erythropoietic cells – the pathogenesis of anemia of chronic disease. Although iron stores (ferritin) may even be higher than needed. Do you agree? And how would you explain the increase in MCV in this case?