
Neutrophil Hypersegmentation: Diagnostic Criteria
Laboratory criteria for neutrophil hypersegmentation in a complete blood count: hereditary forms, megaloblastic anemia, and the impact of cytostatic therapy.
Topic

Laboratory criteria for neutrophil hypersegmentation in a complete blood count: hereditary forms, megaloblastic anemia, and the impact of cytostatic therapy.

Clinical case: An 8-year-old boy with hepatosplenomegaly and pancytopenia. Bone marrow aspirate shows altered macrophages. Determine the diagnosis.

Cytological features of osteoblasts in bone marrow aspirates: morphology of large cells with eccentric nuclei and differentiation from plasma cells.

Erythrocyte morphology in blood smears in anemia: detection of basophilic stippling, its clinical and diagnostic significance, and causes.

What neutrophil hypogranulation in a blood smear means: diagnostic significance in severe infections and myelodysplastic syndrome (MDS).

What are blood chimeras and why do two erythrocyte populations arise? Features of the double field reaction in Rh and Kell system antigen typing.

What is blood chimerism? Learn about the causes of a dual red blood cell population and the specifics of Rh and Kell antigen phenotyping using gel cards.

What is blood chimerism, why does a mixed erythrocyte population occur, and how does it manifest in immunohematological analysis on a gel card.

What neutrophil vacuolization in a blood smear means: a marker of severe bacterial infection, sepsis, or an artifact of prolonged EDTA sample storage.

What are Cabot rings in erythrocytes? Morphological features, causes of appearance in megaloblastic anemia and myelodysplastic syndrome.

The phenomenon of emperipolesis in bone marrow: active penetration of intact cells into the megakaryocyte cytoplasm in a puncture smear.

What toxic granulation of neutrophils in a blood smear means. Mechanism of granule formation, connection to infection severity, sepsis, and clinical significance.