
Differential Diagnosis of Iron Metabolism Disorders
Comparative table of iron and heme metabolism disorders: IDA, anemia of chronic disease, hemochromatosis, sideroblastic anemia, and porphyrias.
Topic

Comparative table of iron and heme metabolism disorders: IDA, anemia of chronic disease, hemochromatosis, sideroblastic anemia, and porphyrias.

Clinical case: a one-year-old child presents with agranulocytosis, rash, and fever. Evaluate the complete blood count, possible causes, and emergency measures.

Stages of granulocytic maturation in bone marrow: morphology of myelocytes, metamyelocytes, and mature granulocytes under microscopy.

Blood smear morphology in Evans Syndrome: severe hemolysis, polychromasia, basophilic stippling, Howell-Jolly bodies, and normoblasts in peripheral blood.

Laboratory algorithm for differential diagnosis of microcytic hypochromic anemias: ferritin, iron, TIBC, and transferrin saturation.

Diagram of mean corpuscular volume (MCV) changes. Pathogenesis of microcytosis and macrocytosis in iron deficiency, vitamin B12 deficiency, folate deficiency, and liver pathologies.

Clinical case of mucopolysaccharidosis type VI: coarse azurophilic granulation of neutrophils and monocytes in a blood smear, arylsulfatase B enzyme deficiency.

Clinical digital microscopy exercise: identify the misclassified leukocyte in a gallery of normoblasts (NRBCs) in hemolytic disease of the newborn.

A clinical case of congenital dyserythropoietic anemia in a child: erythrocyte morphology, basophilic stippling, and complete blood count parameters.

A clinical case of Chédiak–Higashi syndrome in a child: giant granules in the cytoplasm of granulocytes and mononuclear cells in a peripheral blood smear.

How to evaluate a bone marrow smear without patient history: differentiating hematopoietic lineages, cellularity, and maturation signs of granulocytes and normoblasts.

Morphological variants of plasma cells: flaming plasma cells, Mott cells with Russell bodies, and atypical forms with rod-like inclusions.