
Unusual Erythrocyte Morphology Artifacts in Blood Smears
Erythrocyte morphology and artifacts in peripheral blood smears: evaluating cell shape, causes of artifactual clearings and fixation defects.
Topic

Erythrocyte morphology and artifacts in peripheral blood smears: evaluating cell shape, causes of artifactual clearings and fixation defects.

Impact of cold agglutination on CBC parameters: falsely elevated MCHC, spurious erythrocytopenia, and correction by warming to 37 °C.

Why hemoglobin and hematocrit levels don't always reflect acute blood loss severity: clinical parameter assessment and risks of unjustified blood transfusion.

Analysis of a complete blood count in a patient with ARVI: moderate leukopenia, relative monocytosis, and clinical interpretation of the leukocyte differential.

External manifestations of major beta-thalassemia: facial bone deformities, cutaneous hemosiderosis in severe hemolytic anemia and iron overload.

Cold agglutinin disease: mechanism of autoimmune hemolysis by IgM antibodies, symptoms, and features of cold agglutination of erythrocytes in blood tests.

Clinical signs of sideropenic syndrome in iron deficiency anemia: atrophy of tongue papillae, angular stomatitis, and koilonychia (spoon-shaped nails).

Morphological features of atypical mononuclear cells (virocytes) in blood smears: nuclear polymorphism, cytoplasmic basophilia, and infection diagnosis.

Clinical case: atypical mononuclear cells (32%) and leukocytosis 21.38×10⁹/L in a 23-year-old female patient. Sysmex WDF and WPC scattergrams, cytology, and leukocyte differential.

Normal erythrocyte lifespan: physiology of red blood cells, elasticity, splenic clearance, and metabolic features.

Features of differential leukocyte count in severe leukopenia: detection of large granular lymphocytes, WDF scattergram analysis, and digital microscopy.

Morphology of atypical mononuclear cells (reactive lymphocytes) in peripheral blood smear in infectious mononucleosis. Microphotograph atlas.