Oncohematology on Leukoformula

Diffuse Large B-Cell Lymphoma in Lymph Node Imprint

Tue, 19 May 2026 10:00:02 +0300

Imprint smear of a cervical lymph node from a 78-year-old woman.

Diagnosis based on HI and IHC results: diffuse large B-cell lymphoma (non-GCB, double expressor).

🙏 The publication was kindly provided by Elena Belyakova, Clinical Laboratory Diagnostics Physician, Pathologist, member of the FLM Hematology Committee, Department of Molecular Morphology, E.E. Eichwald Clinic, I.I. Mechnikov Northwestern State Medical University, St. Petersburg.

Acute Myeloid Leukemia Without Maturation: Blast Morphology

Wed, 13 May 2026 18:00:00 +0300

There is a pronounced recurrence in the arrangement of blast cells in a patient with acute myeloid leukemia without maturation.

🔬 Source: from the archive of Brazilian hematology specialist Marcio Melo

Bone Marrow Erythroid Lineage in Multiple Myeloma

Mon, 11 May 2026 08:00:00 +0300

Patient, 71 years old, diagnosed with multiple myeloma.

Complete blood count:

RBC 3.6×10^12/L

HGB 128 g/L

WBC 4.0 g/L

PLT 210×10^9/L

ESR 18 mm/hour.

In the control bone marrow aspirate, after a course of treatment, the erythroid lineage of hematopoiesis is expanded to 47.5% (normal range 14.5-26.5). Binucleated erythrokaryocytes (photo 2, 3) and mitotic figures (photo 5) are observed.

Marginal Zone Lymphoma: Atypical Lymphocytes in Blood Smear

Sat, 02 May 2026 08:00:01 +0300

B-cell MARGINAL ZONE LYMPHOMA (confirmed). In the patient’s CBC - moderate anemia and thrombocytopenia - RBC 3.65×10^{12/L
HGB 116 g/L,
PLT 100×10}9/L, Leukocytosis, RDW 73.22×10^9/L, with absolute lymphocytosis and neutropenia. In the photographs - ATYPICAL lymphocytes. Receiving treatment.

Myelogram in Suspected Lymphoproliferative Disease

Wed, 29 Apr 2026 08:00:00 +0300

PATIENT is 22 years old. Sternal puncture was prescribed to rule out lymphoproliferative disease.

In peripheral blood - moderate leukocytosis, other parameters are normal.

In the BONE MARROW ASPIRATE, the number of lymphocytes is slightly increased - 22.6% (N 4.3-13.7%), plasma cells 0.6 (N 0.4 - 1.8).

Chronic Lymphocytic Leukemia: A Diagnostic Case Study

Wed, 22 Apr 2026 09:00:01 +0300

The patient was admitted for further examination and diagnosis.

He considers himself ill for about a month, when he began to experience fatigue, tiredness, and severe sweating, but continued to work and did not seek medical attention. He began to be examined in early April 2026, with leukocytosis up to 500x10*9/L in the complete blood count, lymphocytosis of 98%, total spleen area of 98 sq cm on abdominal ultrasound, abdominal lymphadenopathy up to 3 cm, and enlargement of submandibular, cervical, supraclavicular, axillary, iliac, and inguinal lymph nodes up to 2-3 cm.

Acute Myeloblastic Leukemia Without Maturation (FAB M1)

Tue, 21 Apr 2026 18:00:00 +0300

A patient with suspected acute leukemia. A complete blood count was performed, and the diagnosis was confirmed.

Marked leukocytosis was noted, with more than 90 percent of cells being myeloblasts. The picture corresponds to acute myeloblastic leukemia without maturation, variant 1 according to the French-American-British classification.

Blasts in Peripheral Blood Smear with Pancytopenia

Tue, 14 Apr 2026 09:00:01 +0300

Blasts🔬

A patient was admitted to the emergency department. Complete blood count results: HGB -55; PLT- 41; WBC- 2.1. When counting the differential white blood cell count, 19% blasts were found!

Acute Lymphoblastic Leukemia: Cytochemistry and Blast Morphology

Fri, 10 Apr 2026 10:00:01 +0300

TRILINEAGE cytopenia in a 75-year-old patient. Bone marrow aspirate shows total blast infiltration. The cytoplasm is basophilic with vacuolization. Myeloperoxidase reaction in blasts is negative. PAS reaction is positive in granular form. The morphocytochemical characteristics correspond to lymphoid lineage – a picture of acute lymphoblastic leukemia.

Blasts in Peripheral Blood in Acute Leukemia

Wed, 08 Apr 2026 11:00:00 +0300

BLASTS.

Peripheral blood of a patient with acute leukemia.

🙏 The publication was kindly provided by the clinical diagnostic laboratory physician Nana Novikova, CHUZ “Clinical Hospital” RZHD-Meditsina, Smolensk.

Acute Leukemia in a Rat: Blast Morphology in Blood Smear

Tue, 31 Mar 2026 09:00:00 +0300

Peripheral blood of a rat. Patient: 1 year old.

Total white blood cell count: 258 thousand/µL

Romanowsky-Giemsa stain, magnification x1000

🙏 Publication kindly provided by hematologist of the VETLAB veterinary laboratory network Amira Kuznetsova, Moscow

Leukemization of Lymphoma: Atypical Lymphocytes in Blood Smear

Wed, 25 Mar 2026 09:00:01 +0300

A 54-year-old patient from the hematology department, diagnosed with lymphoma.

The complete blood count shows severe anemia, anisocytosis and poikilocytosis of erythrocytes; leukocytosis with lymphocytosis, predominantly represented by abnormal lymphocytes (blasts?), with irregular nuclear shapes, indistinct nucleoli, finely dispersed chromatin, some with vacuolated cytoplasm.

Acute Leukemia: Blast Morphology in Complete Blood Count

Mon, 23 Feb 2026 09:00:01 +0300

Acute leukemia in a patient who presented with complaints of epistaxis and general weakness. Age 21 years. Blastosis. The last medical examination was in 2025, and CBC parameters were normal.

Dysgranulocytopoiesis in Blood Smear: Suspected Myelodysplastic Syndrome

Wed, 18 Feb 2026 18:30:00 +0300

A 75-year-old patient reports severe fatigue and weakness for about a month. He has not seen a therapist; his medical history only includes inpatient treatment for surgery (hernia repair).

Plasma Cells in Bone Marrow in Multiple Myeloma

Mon, 09 Feb 2026 08:00:01 +0300

The patient was referred for a consultation with a hematologist due to anemia and leukocytosis. Bone marrow was taken, in which the number of plasma cells was increased. At the patient’s next appointment, hospitalization will likely be offered for further examination and treatment of the disease. At this stage, morphologically, multiple myeloma can be suspected.

Acute Leukemia in a Child: Blastemia and Hyperleukocytosis

Wed, 28 Jan 2026 09:00:00 +0300

A child was admitted to the emergency department of a hospital. A 14-year-old girl. Leukocytes - 172. Platelets - 84. Hemoglobin - 111. Blasts - 95%. The child was transferred to the oncohematology department of another institution.

Extramedullary Disease in Multiple Myeloma: Forms & Diagnosis

Tue, 06 Jan 2026 20:00:00 +0300

🔬 What is extramedullary disease in myeloma?

Extramedullary disease is an aggressive condition in which malignant plasma cells migrate outside the bone marrow and form tumors in soft tissues or organs. It is one of the most challenging manifestations of myeloma, often resistant to therapy and associated with an unfavorable prognosis.

Blood and Bone Marrow Findings in Chronic Lymphocytic Leukemia

Sat, 15 Nov 2025 09:22:00 +0300

In the patient’s CBC, with a confirmed diagnosis of CLL, leukocytosis (92.9) with absolute lymphocytosis (89%) was observed.

In the bone marrow aspirate, there was tumor infiltration – lymphocytes with clumpy, condensed nuclear chromatin. Cytolysis cells were present.

Acute Myeloid Leukemia: Blasts and Auer Rods in Blood

Tue, 24 Jun 2025 08:00:01 +0300

⚠ 97% blasts and Auer rods

Female, 75 years old.

🔬 Complete Blood Count:

Leukocytes — 181.76 ×10⁹/L
Erythrocytes — 2.84 ×10¹²/L
Hemoglobin — 85 g/L
Platelets — 49 ×10⁹/L

🩸 In the peripheral blood smear — 97% blasts, some with Auer rods. Some cells have nuclei with “angel wings” morphology.

Dendritic Cell Neoplasm: Bone Marrow Cell Morphology

Mon, 23 Jun 2025 20:41:27 +0300

❗ A young woman was admitted with agranulocytosis. Laboratory parameters on admission:

🩸 CBC: Hemoglobin — 85 g/L Red blood cells — 2.7×10¹²/L White blood cells — 0.7×10⁹/L Platelets — 221×10⁹/L

Acute Leukemia in a Child: Blasts in Peripheral Blood

Wed, 11 Jun 2025 10:00:02 +0300

🔬 Newly diagnosed acute leukemia in a 10-year-old girl

Admitted to the emergency department with complaints of fatigue, fever, and painful “sores” on her lips.

📋 Tests:

Leukocytosis 500 × 10⁹/L (!),
Mild anemia,
Thrombocytopenia.

🩸 Upon microscopy:

Blasts in Peripheral Blood Smear: Cell Morphology

Thu, 05 Jun 2025 13:30:00 +0300

🔬 A solitary blast found in a peripheral blood smear.

🙏 Image kindly provided by Clinical Laboratory Diagnostics Physician, Anna Ivanova, Moscow.

Multiple Myeloma with Normal CBC and Urinalysis Results

Tue, 13 May 2025 19:00:01 +0300

🔍 Unusual case: perfect blood and urine tests, but… myeloma!

A 40-year-old patient presented with shooting lower back pain, but general blood and urine tests showed practically normal results:

MDS with Erythroid Dysplasia of the Bone Marrow

Fri, 19 Jul 2024 12:42:07 +0300

A 65-year-old female patient with pancytopenia in peripheral blood. MDS with hyperplasia and severe dysplasia of the erythroid lineage of the bone marrow.

🔬The case was kindly shared by the Head of the Morphology/IFT Department of the Ha-Emek Medical Center Laboratory, Afula 🇮🇱Israel - Anna Belen.

Myeloperoxidase Staining in Myelomonocytic Leukemia

Thu, 15 Feb 2024 13:00:00 +0300

🔬❗Staining of bone marrow aspirate — with benzidine manufactured in 1974. We decided to check if it would still work… And imagine, it works!

The diagnosis for a 35-year-old man is acute myelomonocytic leukemia (verified by flow cytometry - MPO+).

Intravascular Large B-Cell Lymphoma: A Case Study

Sat, 04 Nov 2023 14:00:00 +0300

😱A clinical case of lymphoma-induced nightmares.

A 56-year-old woman presented to a neurologist with multiple neurological symptoms — nightmares, unusual headaches, and dizziness. She also developed a fever and abdominal pain.

Acute Monocytic Leukemia M5b: Cell Morphology and Immunophenotyping

Mon, 21 Aug 2023 18:45:00 +0300

A case of diagnosing 500,000 leukocytosis!

After processing a blood sample from an outpatient clinic (male, 71 years old) and obtaining this result, doubts arose about its reliability: Leuk. 503×10⁹/L (the analyzer’s cell distribution across all possible channels only added to the uncertainty), Hgb 85 g/L, Platelets 196×10⁹/L. We repeated the analysis, while a smear was prepared and the patient’s history was reviewed. The result was repeated, and in June 2022, the patient was diagnosed with Diffuse Large B-cell Lymphoma of the soft tissues of the back. He underwent chemotherapy. At present (end of July 2023), we have no clinical data.

Acute Promyelocytic Leukemia: Hypogranular Variant M3v

Wed, 01 Mar 2023 08:00:03 +0300

🔬“Angel Wings” 🩸in the blood of a patient with acute promyelocytic leukemia.

✅The photograph shows a bone marrow aspirate, where atypical promyelocytes have abundant basophilic cytoplasm, as well as a specific nuclear shape (“Angel Wings”🕊 or also called “Butterfly Wings”🦋).